Machine learning-guided protein engineering
Recent progress in engineering highly promising biocatalysts has increasingly involved
machine learning methods. These methods leverage existing experimental and simulation …
machine learning methods. These methods leverage existing experimental and simulation …
Machine learning-enabled retrobiosynthesis of molecules
Retrobiosynthesis provides an effective and sustainable approach to producing functional
molecules. The past few decades have witnessed a rapid expansion of biosynthetic …
molecules. The past few decades have witnessed a rapid expansion of biosynthetic …
Bio-inspired design of an in situ multifunctional polymeric solid–electrolyte interphase for Zn metal anode cycling at 30 mA cm− 2 and 30 mA h cm− 2
A solid–electrolyte interphase (SEI) is highly desirable to restrain Zn dendrite growth and
side reactions between a Zn anode and water in rechargeable aqueous zinc-ion batteries …
side reactions between a Zn anode and water in rechargeable aqueous zinc-ion batteries …
Self-play reinforcement learning guides protein engineering
Y Wang, H Tang, L Huang, L Pan, L Yang… - Nature Machine …, 2023 - nature.com
Designing protein sequences towards desired properties is a fundamental goal of protein
engineering, with applications in drug discovery and enzymatic engineering. Machine …
engineering, with applications in drug discovery and enzymatic engineering. Machine …
xTrimoPGLM: unified 100B-scale pre-trained transformer for deciphering the language of protein
Protein language models have shown remarkable success in learning biological information
from protein sequences. However, most existing models are limited by either autoencoding …
from protein sequences. However, most existing models are limited by either autoencoding …
[HTML][HTML] Evolutionary velocity with protein language models predicts evolutionary dynamics of diverse proteins
The degree to which evolution is predictable is a fundamental question in biology. Previous
attempts to predict the evolution of protein sequences have been limited to specific proteins …
attempts to predict the evolution of protein sequences have been limited to specific proteins …
Machine learning to navigate fitness landscapes for protein engineering
CR Freschlin, SA Fahlberg, PA Romero - Current opinion in biotechnology, 2022 - Elsevier
Machine learning (ML) is revolutionizing our ability to understand and predict the complex
relationships between protein sequence, structure, and function. Predictive sequence …
relationships between protein sequence, structure, and function. Predictive sequence …
Artificial intelligence-aided protein engineering: from topological data analysis to deep protein language models
Protein engineering is an emerging field in biotechnology that has the potential to
revolutionize various areas, such as antibody design, drug discovery, food security, ecology …
revolutionize various areas, such as antibody design, drug discovery, food security, ecology …
Priority and prospect of sulfide‐based solid‐electrolyte membrane
H Liu, Y Liang, C Wang, D Li, X Yan… - Advanced …, 2023 - Wiley Online Library
All‐solid‐state lithium batteries (ASSLBs) employing sulfide solid electrolytes (SEs) promise
sustainable energy storage systems with energy‐dense integration and critical intrinsic …
sustainable energy storage systems with energy‐dense integration and critical intrinsic …
Persistent spectral theory-guided protein engineering
Although protein engineering, which iteratively optimizes protein fitness by screening the
gigantic mutational space, is constrained by experimental capacity, various machine …
gigantic mutational space, is constrained by experimental capacity, various machine …