Studies with perforin-deficient mice have demonstrated that two independent mechanisms
account for T cell–mediated cytotoxicity: A main pathway is mediated by the secretion of the …

The cytolytic potential of T effector cells appears to be intimately related to the presence of
proteins stored in specialized cytoplasmic granules. A striking biological property of isolated …

Perforin-deficient mice have been generated by homologous recombination to determine
whether the effects of CDS+ cytolytic T cells and natural killer cells are mediated by pore …

Mutations in the perforin gene have been described in some patients with hemophagocytic
lymphohistiocytosis (HLH), but the role of perforin defects in the pathogenesis of HLH …

To prevent uncontrolled expansion, the massive proliferation of T cells during an acute
immune response has to be followed by controlled deletion. Here we show that similar to …

Lichen planus (LP) is a chronic inflammatory disorder involving cutaneous and mucosal
surfaces, characterized by a T‐cell‐mediated immune response against epithelial cells, with …

Revised Manuscript Received August 23, 1990 abstract: Cytolytic T-lymphocytes (CTL)
harborcytoplasmic granules containing the lytic, pore-forming protein perforin, a family of …

Granzymes are serine proteases present in secretory granules of cytolytic T lymphocyte
lines. We have studied the expression of the granzyme family (granzyme A, B, C, D, E, F …

Abstract Background Granzyme B (GrB) is a serine protease, traditionally known as
expressed by cytotoxic lymphocytes to induce target cell apoptosis. However, it is emerging …

Granzyme B (GrB) is a serine proteinase known to be expressed by cytotoxic lymphocytes
and to induce, in presence of perforin (Pf), apoptosis in target cells. Recently, GrB …