Mining electronic health records: towards better research applications and clinical care
Clinical data describing the phenotypes and treatment of patients represents an underused
data source that has much greater research potential than is currently realized. Mining of …
data source that has much greater research potential than is currently realized. Mining of …
[HTML][HTML] The electronic medical records and genomics (eMERGE) network: past, present, and future
Abstract The Electronic Medical Records and Genomics Network is a National Human
Genome Research Institute–funded consortium engaged in the development of methods …
Genome Research Institute–funded consortium engaged in the development of methods …
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges
B Piasecka, D Duffy, A Urrutia… - Proceedings of the …, 2018 - National Acad Sciences
The contribution of host genetic and nongenetic factors to immunological differences in
humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral …
humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral …
Validation of electronic medical record-based phenotyping algorithms: results and lessons learned from the eMERGE network
KM Newton, PL Peissig, AN Kho… - Journal of the …, 2013 - academic.oup.com
Background Genetic studies require precise phenotype definitions, but electronic medical
record (EMR) phenotype data are recorded inconsistently and in a variety of formats …
record (EMR) phenotype data are recorded inconsistently and in a variety of formats …
Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers
We report∼ 17.6 million genetic variants from whole-genome sequencing of 2,120
Sardinians; 22% are absent from previous sequencing-based compilations and are …
Sardinians; 22% are absent from previous sequencing-based compilations and are …
[HTML][HTML] Secondary use of clinical data: the Vanderbilt approach
The last decade has seen an exponential growth in the quantity of clinical data collected
nationwide, triggering an increase in opportunities to reuse the data for biomedical research …
nationwide, triggering an increase in opportunities to reuse the data for biomedical research …
Design and anticipated outcomes of the eMERGE‐PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems
LJ Rasmussen‐Torvik, SC Stallings… - Clinical …, 2014 - Wiley Online Library
We describe here the design and initial implementation of the eMERGE‐PGx project.
eMERGE‐PGx, a partnership of the Electronic Medical Records and Genomics Network and …
eMERGE‐PGx, a partnership of the Electronic Medical Records and Genomics Network and …
[PDF][PDF] Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome-and phenome-wide studies
We repurposed existing genotypes in DNA biobanks across the Electronic Medical Records
and Genomics network to perform a genome-wide association study for primary …
and Genomics network to perform a genome-wide association study for primary …
Electronic medical record phenotyping using the anchor and learn framework
ABSTRACT Background Electronic medical records (EMRs) hold a tremendous amount of
information about patients that is relevant to determining the optimal approach to patient …
information about patients that is relevant to determining the optimal approach to patient …
[HTML][HTML] Extracting research-quality phenotypes from electronic health records to support precision medicine
The convergence of two rapidly developing technologies-high-throughput genotyping and
electronic health records (EHRs)-gives scientists an unprecedented opportunity to utilize …
electronic health records (EHRs)-gives scientists an unprecedented opportunity to utilize …