For more than a decade, it has been known that mammalian cells use shelterin to protect
chromosome ends. Much progress has been made on the mechanism by which shelterin …

Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes,
whose length is considered to be a determinant of biological ageing. Normal ageing itself is …

In DNA repair, the resection of double-strand breaks dictates the choice between homology-
directed repair—which requires a 3′ overhang—and classical non-homologous end …

We have applied a super-resolution fluorescence imaging method, stochastic optical
reconstruction microscopy (STORM), to visualize the structure of functional telomeres and …

The Alternative Lengthening of Telomeres (ALT) pathway is a telomerase-independent
pathway for telomere maintenance that is active in a significant subset of human cancers …

The telomere end-protection problem is defined by the aggregate of DNA damage signaling
and repair pathways that require repression at telomeres. To define the end-protection …

Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are
progressively lost with each round of cell division. Telomere protection requires a minimal …

Telomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal
bodies, and telomerase is thought to be recruited to telomeres through interactions with …

In mammals, maintenance of the linear chromosome ends (or telomeres) involves faithful
replication of genetic materials and protection against DNA damage signals, to ensure …

Telomere length measurement is increasingly recognized as a clinical gauge for age-related
disease risk. There are several methods for studying blood telomere length (BTL) as a …