A molecular robot, which is a system comprised of one or more molecular machines and
computers, can execute sophisticated tasks in many fields that span from nanomedicine to …

β barrels are ubiquitous proteins in the outer membranes of mitochondria, chloroplasts, and
Gram-negative bacteria. These transmembrane proteins (TMPs) execute a wide variety of …

We describe an approach for designing high-affinity small molecule–binding proteins poised
for downstream sensing. We use deep learning–generated pseudocycles with repeating …

There is a current need to develop methods for the sensitive detection of peptide biomarkers
in complex mixtures of molecules, such as biofluids, to enable early disease detection …

The rapid progress in nanopore sensing has sparked interest in protein sequencing. Despite
recent notable advancements in amino acid recognition using nanopores, chemical …

Fluorescent nanomaterials such as carbon quantum dots (CQDs) have been widely utilized
as optical nanosensors for the detection and imaging of chemical or biological species with …

The development of novel methodologies that can detect biomarkers from cancer or other
diseases is both a challenge and a need for clinical applications. This partly motivates efforts …

Nanopores offer highly sensitive, low-cost, and single-molecule sensing capabilities, and
the societal impact of this approach is best captured by the advent of nanopore-based DNA …

Nanopores are currently utilized as powerful tools for single-molecule protein sensing. The
reporting signal typically requires protein analytes to enter the nanopore interior, yet a class …

Transcription factors often interact with other protein cofactors, regulating gene expression.
Direct detection of these brief events using existing technologies remains challenging due to …