Review of applications and future prospects of stimuli-responsive hydrogel based on thermo-responsive biopolymers in drug delivery systems

S Chatterjee, PC Hui - Polymers, 2021 - mdpi.com
Some of thermo-responsive polysaccharides, namely, cellulose, xyloglucan, and chitosan,
and protein-like gelatin or elastin-like polypeptides can exhibit temperature dependent sol …

Nanomaterial-based delivery of vaccine through nasal route: opportunities, challenges, advantages, and limitations

M Kumar, R Dogra, UK Mandal - Journal of Drug Delivery Science and …, 2022 - Elsevier
Mucosal administration especially via the nasal route is a novel and promising technique for
medication and vaccine delivery. Mucosal pathways provide notable benefits that promote …

Self-assembled lecithin-chitosan nanoparticles improved rotigotine nose-to-brain delivery and brain targeting efficiency

P Saha, P Singh, H Kathuria, D Chitkara, MM Pandey - Pharmaceutics, 2023 - mdpi.com
Rotigotine (RTG) is a non-ergoline dopamine agonist and an approved drug for treating
Parkinson's disease. However, its clinical use is limited due to various problems, viz. poor …

Optimization and in vivo evaluation of triamcinolone acetonide loaded in situ gel prepared using reacted tamarind seed xyloglucan and kappa-carrageenan for ocular …

MS Khan, PR Ravi, SI Mir, PS Rawat - International Journal of Biological …, 2023 - Elsevier
In the current work, triamcinolone acetonide (TAA) loaded dual responsive in situ gelling
system was designed and optimized using reacted tamarind seed xyloglucan (RXG) …

Nose-to-brain delivery of rotigotine redispersible nanosuspension: In vitro and in vivo characterization

P Saha, H Kathuria, MM Pandey - Journal of Drug Delivery Science and …, 2023 - Elsevier
Rotigotine (RTG) is an anti-Parkinson's drug approved by the USFDA to treat motor and non-
motor symptoms of both early and advanced stages of the disease. However, issues like …

Polysaccharide-based platforms for nasal delivery: design, features, and perspectives

E Elmowafy, ME Soliman - Journal of Pharmaceutical Investigation, 2023 - Springer
Background Polysaccharides acceded by the Food and Drug Administration are among the
most exploitable polymers for fabricating nasally applied vehicles containing therapeutically …

Preparation and Optimization of Liposome Containing Thermosensitive In Situ Nasal Hydrogel System for Brain Delivery of Sumatriptan Succinate

D Mathure, AD Sutar, H Ranpise, A Pawar… - ASSAY and Drug …, 2023 - liebertpub.com
Drug absorption is improved by the intranasal route's wide surface area and avoidance of
first-pass metabolism. For the treatment of central nervous system diseases such as …

Biomaterials for drugs nose–brain transport: a new therapeutic approach for neurological diseases

R Cassano, C Servidio, S Trombino - Materials, 2021 - mdpi.com
In the last years, neurological diseases have resulted in a global health issue, representing
the first cause of disability worldwide. Current therapeutic approaches against neurological …

Design and evaluation of rufinamide nanocrystals loaded thermoresponsive nasal in situ gelling system for improved drug distribution to brain

A Dalvi, PR Ravi, CT Uppuluri - Frontiers in Pharmacology, 2022 - frontiersin.org
Rufinamide (Rufi) is an antiepileptic drug used to manage Lennox-Gastaut Syndrome and
partial seizures. The oral bioavailability of Rufi is less due to its poor solubility and low …

Rufinamide-Loaded Chitosan Nanoparticles in Xyloglucan-Based Thermoresponsive In Situ Gel for Direct Nose to Brain Delivery

A Dalvi, PR Ravi, CT Uppuluri - Frontiers in Pharmacology, 2021 - frontiersin.org
In 2004, the US FDA approved Rufinamide, an anti-epileptic drug under the brand name
Banzel®. In 2015, Banzel® received approval for its use in pediatric patients (ages 1–4 …