Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase
that regulates an enormous variety of cellular functions through the interaction of its catalytic …

Ceulemans, Hugo, and Mathieu Bollen. Functional Diversity of Protein Phosphatase-1, a
Cellular Economizer and Reset Button. Physiol Rev 84: 1–39, 2004; 10.1152/physrev …

Phosphorylation of myosin II plays an important role in many cell functions, including smooth
muscle contraction. The level of myosin II phosphorylation is determined by activities of …

The coordinated and reciprocal action of serine/threonine (Ser/Thr) protein kinases and
phosphatases produces transient phosphorylation, a fundamental regulatory mechanism for …

The catalytic subunit of the type 1 Ser/Thr protein phosphatases (PP1) can interact with
many different regulatory (R) subunits. These R subunits function as activity-modulators …

Skeletal muscle myosin light chain kinase (skMLCK) is a dedicated Ca2+/calmodulin-
dependent serine–threonine protein kinase that phosphorylates the regulatory light chain …

Many protein kinases are activated by a conserved regulatory step involving T-loop
phosphorylation. Although there is considerable focus on kinase activator proteins, the …

Most interactors of protein phosphatase-1 (PP1) contain a variant of a so-called" RVXF"
sequence that binds to a hydrophobic groove of the catalytic subunit. A combination of …

Protein phosphatase type 1 (PP1) 1 is involved in a wide range of cell activities (1), and
even within the more restricted theme of contractile activity in muscle several processes may …

Phosphorylation of myosin II is important in many aspects of cell function and involves a
myosin kinase, eg myosin light chain kinase, and a myosin phosphatase (MP). MP is …