Advances in the Chemistry of Astatine and Implications for the Development of Radiopharmaceuticals

F Guérard, C Maingueneau, L Liu… - Accounts of Chemical …, 2021 - ACS Publications
Conspectus Astatine (At) is the rarest on Earth of all naturally occurring elements, situated
below iodine in the periodic table. While only short-lived isotopes (t 1/2≤ 8.1 h) are known …

Recent progress of astatine-211 in endoradiotherapy: Great advances from fundamental properties to targeted radiopharmaceuticals

F Li, Y Yang, J Liao, N Liu - Chinese Chemical Letters, 2022 - Elsevier
Abstract Astatine-211 (211 At, t 1/2= 7.21 h) emitting two α particles with energies of 5.87
and 7.45 MeV, can lead to a high linear energy transfer (LET= 98.84 keV/µm) and short …

The electron affinity of astatine

D Leimbach, J Karls, Y Guo, R Ahmed, J Ballof… - Nature …, 2020 - nature.com
One of the most important properties influencing the chemical behavior of an element is the
electron affinity (EA). Among the remaining elements with unknown EA is astatine, where …

Trastuzumab-Modified Gold Nanoparticles Labeled with 211At as a Prospective Tool for Local Treatment of HER2-Positive Breast Cancer

Ł Dziawer, A Majkowska-Pilip, D Gaweł, M Godlewska… - Nanomaterials, 2019 - mdpi.com
Highly localized radiotherapy with radionuclides is a commonly used treatment modality for
patients with unresectable solid tumors. Herein, we propose a novel α-nanobrachytherapy …

Measurement of the first ionization potential of astatine by laser ionization spectroscopy

S Rothe, AN Andreyev, S Antalic, A Borschevsky… - Nature …, 2013 - nature.com
The radioactive element astatine exists only in trace amounts in nature. Its properties can
therefore only be explored by study of the minute quantities of artificially produced isotopes …

Experimental and computational evidence of halogen bonds involving astatine

N Guo, R Maurice, D Teze, J Graton, J Champion… - Nature Chemistry, 2018 - nature.com
The importance of halogen bonds—highly directional interactions between an electron-
deficient σ-hole moiety in a halogenated compound and an acceptor such as a Lewis base …

Nanoparticles in targeted alpha therapy

A Majkowska-Pilip, W Gawęda… - Nanomaterials, 2020 - mdpi.com
Recent advances in the field of nanotechnology application in nuclear medicine offer the
promise of better therapeutic options. In recent years, increasing efforts have been made on …

Gold nanoparticle bioconjugates labelled with 211 At for targeted alpha therapy

L Dziawer, P Koźmiński, S Męczyńska-Wielgosz… - RSC …, 2017 - pubs.rsc.org
Alpha particle emitting isotopes are of considerable interest for radionuclide therapy
because of their high cytotoxicity and short path length. Due to the relatively high availability …

Targeted radionuclide therapy with astatine-211: Oxidative dehalogenation of astatobenzoate conjugates

D Teze, DC Sergentu, V Kalichuk, J Barbet… - Scientific Reports, 2017 - nature.com
Abstract 211At is a most promising radionuclide for targeted alpha therapy. However, its
limited availability and poorly known basic chemistry hamper its use. Based on the analogy …

QTAIM analysis in the context of quasirelativistic quantum calculations

J Pilme, E Renault, F Bassal, M Amaouch… - Journal of Chemical …, 2014 - ACS Publications
Computational chemistry currently lacks ad hoc tools for probing the nature of chemical
bonds in heavy and superheavy-atom systems where the consideration of spin–orbit …