Advances in the Chemistry of Astatine and Implications for the Development of Radiopharmaceuticals
F Guérard, C Maingueneau, L Liu… - Accounts of Chemical …, 2021 - ACS Publications
Conspectus Astatine (At) is the rarest on Earth of all naturally occurring elements, situated
below iodine in the periodic table. While only short-lived isotopes (t 1/2≤ 8.1 h) are known …
below iodine in the periodic table. While only short-lived isotopes (t 1/2≤ 8.1 h) are known …
Recent progress of astatine-211 in endoradiotherapy: Great advances from fundamental properties to targeted radiopharmaceuticals
F Li, Y Yang, J Liao, N Liu - Chinese Chemical Letters, 2022 - Elsevier
Abstract Astatine-211 (211 At, t 1/2= 7.21 h) emitting two α particles with energies of 5.87
and 7.45 MeV, can lead to a high linear energy transfer (LET= 98.84 keV/µm) and short …
and 7.45 MeV, can lead to a high linear energy transfer (LET= 98.84 keV/µm) and short …
The electron affinity of astatine
One of the most important properties influencing the chemical behavior of an element is the
electron affinity (EA). Among the remaining elements with unknown EA is astatine, where …
electron affinity (EA). Among the remaining elements with unknown EA is astatine, where …
Trastuzumab-Modified Gold Nanoparticles Labeled with 211At as a Prospective Tool for Local Treatment of HER2-Positive Breast Cancer
Ł Dziawer, A Majkowska-Pilip, D Gaweł, M Godlewska… - Nanomaterials, 2019 - mdpi.com
Highly localized radiotherapy with radionuclides is a commonly used treatment modality for
patients with unresectable solid tumors. Herein, we propose a novel α-nanobrachytherapy …
patients with unresectable solid tumors. Herein, we propose a novel α-nanobrachytherapy …
Measurement of the first ionization potential of astatine by laser ionization spectroscopy
The radioactive element astatine exists only in trace amounts in nature. Its properties can
therefore only be explored by study of the minute quantities of artificially produced isotopes …
therefore only be explored by study of the minute quantities of artificially produced isotopes …
Experimental and computational evidence of halogen bonds involving astatine
The importance of halogen bonds—highly directional interactions between an electron-
deficient σ-hole moiety in a halogenated compound and an acceptor such as a Lewis base …
deficient σ-hole moiety in a halogenated compound and an acceptor such as a Lewis base …
Nanoparticles in targeted alpha therapy
A Majkowska-Pilip, W Gawęda… - Nanomaterials, 2020 - mdpi.com
Recent advances in the field of nanotechnology application in nuclear medicine offer the
promise of better therapeutic options. In recent years, increasing efforts have been made on …
promise of better therapeutic options. In recent years, increasing efforts have been made on …
Gold nanoparticle bioconjugates labelled with 211 At for targeted alpha therapy
L Dziawer, P Koźmiński, S Męczyńska-Wielgosz… - RSC …, 2017 - pubs.rsc.org
Alpha particle emitting isotopes are of considerable interest for radionuclide therapy
because of their high cytotoxicity and short path length. Due to the relatively high availability …
because of their high cytotoxicity and short path length. Due to the relatively high availability …
Targeted radionuclide therapy with astatine-211: Oxidative dehalogenation of astatobenzoate conjugates
D Teze, DC Sergentu, V Kalichuk, J Barbet… - Scientific Reports, 2017 - nature.com
Abstract 211At is a most promising radionuclide for targeted alpha therapy. However, its
limited availability and poorly known basic chemistry hamper its use. Based on the analogy …
limited availability and poorly known basic chemistry hamper its use. Based on the analogy …
QTAIM analysis in the context of quasirelativistic quantum calculations
Computational chemistry currently lacks ad hoc tools for probing the nature of chemical
bonds in heavy and superheavy-atom systems where the consideration of spin–orbit …
bonds in heavy and superheavy-atom systems where the consideration of spin–orbit …