Anti-interferon-γ autoantibody-associated immunodeficiency

HP Shih, JY Ding, CF Yeh, CY Chi, CL Ku - Current Opinion in Immunology, 2021 - Elsevier
Anticytokine autoantibodies are an emerging disease etiology, through the disturbance of
physiological functions of cognate cytokines. Anti-interferon (IFN)-γ autoantibodies (AIGAs) …

Pathogen spectrum and immunotherapy in patients with anti-IFN-γ autoantibodies: A multicenter retrospective study and systematic review

Y Qiu, G Fang, F Ye, W Zeng, M Tang, X Wei… - Frontiers in …, 2022 - frontiersin.org
Background Anti-interferon-γ autoantibody (AIGA) positivity is an emerging
immunodeficiency syndrome closely associated with intracellular infection in individuals …

Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity

A Cheng, SM Holland - Journal of Allergy and Clinical Immunology, 2022 - Elsevier
Anticytokine autoantibodies can cause immunodeficiency or dysregulate immune
responses. They may phenocopy genetically defined primary immunodeficiencies. We …

Clinical findings of Talaromyces marneffei infection among patients with anti-interferon-γ immunodeficiency: a prospective cohort study

ZM Chen, ZT Li, SQ Li, WJ Guan, Y Qiu, ZY Lei… - BMC Infectious …, 2021 - Springer
Background Talaromyces marneffei (T. marneffei) infection has been associated with adult-
onset immunodeficiency due to anti-IFN-γ autoantibodies. We aimed to investigate the …

Advances in the understanding of talaromycosis in HIV-negative patients (especially in children and patients with hematological malignancies): a comprehensive …

H He, L Cai, Y Lin, F Zheng, W Liao, X Xue… - Medical …, 2024 - academic.oup.com
Talaromyces marneffei (T. marneffei) stands out as the sole thermobiphasic fungus
pathogenic to mammals, including humans, within the fungal community encompassing …

Characteristics and outcomes of anti-interferon gamma antibody-associated adult onset immunodeficiency

B Zhang, J Fan, C Huang, H Fan, J Chen… - Journal of Clinical …, 2023 - Springer
Purpose Anti-interferon gamma antibody (AIGA) is a rare cause of adult onset
immunodeficiency, leading to severe disseminated opportunistic infections with varying …

Minireview: Insights into anti-interferon-γ autoantibodies

K Chawansuntati… - Experimental …, 2021 - journals.sagepub.com
The association between the presence of anti-interferon-γ autoantibodies and the onset of
immunodeficiency with intracellular infections has been clearly established. No standard …

Intravenous Cyclophosphamide Therapy for Anti-IFN-γ Autoantibody-Associated Talaromyces marneffei Infection

W Zeng, M Tang, M Yang, G Fang… - Open Forum …, 2022 - academic.oup.com
High titers of anti-interferon-γ autoantibodies (AIGAs) are an important factor leading to
persistent, relapsed, and refractory infections in HIV-negative hosts infected with …

Anticytokine Autoantibodies in Infectious Diseases: A Practical Overview

RJW Arts, NAF Janssen… - International Journal of …, 2023 - mdpi.com
Anticytokine autoantibodies (ACAAs) are a fascinating group of antibodies that have gained
more and more attention in the field of autoimmunity and secondary immunodeficiencies …

Anticytokine autoantibodies and fungal infections

S Kappagoda, S Deresinski - Journal of Fungi, 2023 - mdpi.com
Anticytokine autoantibodies (ACAAs) can cause adult onset immunodeficiencies which
mimic primary immunodeficiencies and can present as refractory and severe fungal …