The blood–brain barrier (BBB), a unique structure in the central nervous system (CNS),
protects the brain from bloodborne pathogens by its excellent barrier properties …

Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …

Over 30 million people suffer from the consequences of ischemic stroke. The precise
molecular mechanism of neuronal damage during ischemic stroke remains unclear; …

Extravasation is the first step for nanomedicines in circulation to reach targeted solid tumors.
Traditional nanomedicines have been designed to extravasate into tumor interstitium …

Alzheimer's disease (AD), the most common type of senile dementia, includes the complex
pathogenesis of abnormal deposition of amyloid beta-protein (Aβ), phosphorylated tau (p …

In general, iron represents a double-edged sword in metabolism in most tissues, especially
in the brain. Although the high metabolic demands of brain cells require iron as a redox …

Intravenous delivery of nanomaterials containing therapeutic agents and various cargos for
treating neurological disorders is often constrained by low delivery efficacy due to difficulties …

Over the past few decades, the complexity of molecular entities being advanced for
therapeutic purposes has continued to evolve. A main propellent fueling innovation is the …

Brain iron is a crucial participant and regulator of normal physiological activity. However,
excess iron is involved in the formation of free radicals, and has been associated with …

Iron is an essential element that participates in numerous cellular processes. Any disruption
of iron homeostasis leads to either iron deficiency or iron overload, which can be detrimental …