Human germ cell tumours (GCTs) are derived from stem cells of the early embryo and the
germ line. They occur in the gonads (ovaries and testes) and also in extragonadal sites …

The risk for the development of germ cell tumors is an important factor to deal with in the
management of patients with disorders of sex development (DSD). However, this risk is often …

Carcinoma in situ testis (CIS), also known as intratubular germ cell neoplasia (ITGCN), is a
pre-invasive precursor of testicular germ cell tumours, the commonest cancer type of male …

Germ cell tumours (GCTs) are a heterogeneous group of neoplasms, which develop in the
gonads as well as in extragonadal sites, that share morphological patterns and an overall …

Disorders of sex development (DSD), previously referred to as intersex disorders, comprise
a variety of anomalies defined by congenital conditions in which chromosomal, gonadal, or …

Combined action of SOX and POU families of transcription factors plays major roles in
embryonic development. In embryonic stem cells, the combination of SOX2 and POU5F1 …

Context: Gonadectomy is avoided whenever possible in boys with 45, X/46, XY. However,
no clinical markers are currently available to guide clinicians in predicting gonadal tumor …

Certain patients with disorders of sex development (DSD), who bear Y chromosome material
in their karyotype, are at increased risk for the development of type II germ cell tumors (GCT) …

Complete androgen insensitivity syndrome (CAIS) is an X-linked recessive genetic disorder
resulting from maternally inherited or de novo mutations involving the androgen receptor …

Purpose: The purpose of the study was to define the histological origin of gonadoblastomas,
allowing the identification of high-risk patients. Experimental Design: Sixty paraffin …