The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a
simple and scalable way to detect the unique chromatin landscape associated with a cell …

Abstract Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) is widely
used in studying chromatin biology, but a comprehensive review of the analysis tools has …

Only a small proportion of patients with cancer show lasting responses to immune
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …

In many aspects of life, epigenetics, or the altering of phenotype without changes in
sequences, play an essential role in biological function. A vast number of epigenomic …

Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …

Summary Rewiring exhausted CD8+ T (Tex) cells toward functional states remains a
therapeutic challenge. Tex cells are epigenetically programmed by the transcription factor …

Liquid biopsies, in particular, analysis of cell-free DNA (cfDNA), have emerged as a
promising noninvasive diagnostic approach in oncology. Abnormal distribution of DNA …

Abstract i-Motifs (iMs) are four-stranded DNA structures that form at cytosine (C)-rich
sequences in acidic conditions in vitro. Their formation in cells is still under debate. We …

Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8+ T
cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled …

Protective immunity against pathogens or cancer is mediated by the activation and clonal
expansion of antigen-specific naive T cells into effector T cells. To sustain their rapid …