The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …

The therapeutic potential of Cannabis sativa has been recognized since ancient times.
Phytocannabinoids, endocannabinoids and synthetic cannabinoids activate two major G …

This randomized, double-blinded, placebo-controlled trial tested the hypothesis that 20mg of
melatonin before and during the first cycle of adjuvant chemotherapy for breast cancer …

Nerve outgrowth in the tumor microenvironment (tumor neurogenesis) has recently been
shown to be essential for cancer progression and the concept of nerve dependence is …

Purpose Brain-derived neurotrophic factor (BDNF) belongs to the family of neurotrophic
factors that can potentially increase cancer cell growth, survival, proliferation, anoikis, and …

Ischemic stroke can induce neurogenesis. However, most stroke-generated newborn
neurons cannot survive. It has been shown that MR-409, a potent synthetic agonistic analog …

Abstract c-Jun N-terminal kinases (JNKs) play a central role in many physiologic and
pathologic processes. We synthesized novel 11 H-indeno [1, 2-b] quinoxalin-11-one oxime …

MicroRNAs (miRNAs) are small, non-coding RNAs, able to regulate cellular functions by
induction of mRNA degradation and post-transcriptional repression of gene expression …

Recent studies have shown that peripheral nerves play an important role in the progression
of breast cancer. Breast cancer cells (BCCs) promote local peripheral nerve growth and …

Metastasis leads to poor prognosis and reduced disease-free survival in breast cancer
patients, particularly in those with triple-negative breast cancer (TNBC) which is resistant to …