Research priorities towards precision antibiotic therapy to improve patient care
Antibiotic resistance presents an incessant threat to our drug armamentarium that
necessitates novel approaches to therapy. Over the past several decades, investigation of …
necessitates novel approaches to therapy. Over the past several decades, investigation of …
Multidrug resistance (MDR) and collateral sensitivity in bacteria, with special attention to genetic and evolutionary aspects and to the perspectives of antimicrobial …
Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by
adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are …
adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are …
Structural characterization of the D179N and D179Y variants of KPC-2 β-lactamase: Ω-loop destabilization as a mechanism of resistance to ceftazidime-avibactam
TA Alsenani, SL Viviani, V Kumar… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Klebsiella pneumoniae carbapenemases (KPC-2 and KPC-3) present a global clinical
threat, as these β-lactamases confer resistance to carbapenems and oxyimino …
threat, as these β-lactamases confer resistance to carbapenems and oxyimino …
Carbapenem and colistin resistance in Enterobacter: determinants and clones
Z Zong, Y Feng, A McNally - Trends in microbiology, 2021 - cell.com
Enterobacter is a globally important pathogen. Here we clarify its taxonomy and review
recent developments in its resistance to carbapenem and colistin, illustrating that …
recent developments in its resistance to carbapenem and colistin, illustrating that …
The whole is bigger than the sum of its parts: drug transport in the context of two membranes with active efflux
VV Rybenkov, HI Zgurskaya, C Ganguly… - Chemical …, 2021 - ACS Publications
Cell envelope plays a dual role in the life of bacteria by simultaneously protecting it from a
hostile environment and facilitating access to beneficial molecules. At the heart of this ability …
hostile environment and facilitating access to beneficial molecules. At the heart of this ability …
Aztreonam in combination with imipenem-relebactam against clinical and isogenic strains of serine and metallo-β-lactamase-producing enterobacterales
M Biagi, M Lee, T Wu, A Shajee, S Patel… - … and Infectious Disease, 2022 - Elsevier
Objective The objective of this study was to evaluate the in vitro activity of aztreonam plus
imipenem-relebactam against clinical and isogenic strains of Escherichia coli and Klebsiella …
imipenem-relebactam against clinical and isogenic strains of Escherichia coli and Klebsiella …
Penicillin-Binding Protein 5/6 Acting as a Decoy Target in Pseudomonas aeruginosa Identified by Whole-Cell Receptor Binding and Quantitative Systems …
S López-Argüello, M Montaner… - Antimicrobial agents …, 2023 - Am Soc Microbiol
The β-lactam antibiotics have been successfully used for decades to combat susceptible
Pseudomonas aeruginosa, which has a notoriously difficult to penetrate outer membrane …
Pseudomonas aeruginosa, which has a notoriously difficult to penetrate outer membrane …
Mechanistic insights to combating NDM-and CTX-M-coproducing Klebsiella pneumoniae by targeting cell wall synthesis and outer membrane integrity
ABSTRACT Metallo-β-lactamase (MBL)-producing Gram-negative bacteria cause infections
associated with high rates of morbidity and mortality. Currently, a leading regimen to treat …
associated with high rates of morbidity and mortality. Currently, a leading regimen to treat …
First penicillin-binding protein occupancy patterns for 15 β-lactams and β-lactamase inhibitors in Mycobacterium abscessus
Mycobacterium abscessus causes serious infections that often require over 18 months of
antibiotic combination therapy. There is no standard regimen for the treatment of M …
antibiotic combination therapy. There is no standard regimen for the treatment of M …
In vitro antibacterial activity of cefiderocol against recent multidrug-resistant carbapenem-nonsusceptible Enterobacterales isolates
Q Zhang, N Neidig, TY Chu, C Divoky… - … and infectious disease, 2022 - Elsevier
Cefiderocol, a siderophore-containing cephalosporin with broad-spectrum antimicrobial
activity against many β-lactam-resistant Gram-negative bacteria, was tested by broth …
activity against many β-lactam-resistant Gram-negative bacteria, was tested by broth …