Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and
plays an important role in the melanogenesis and enzymatic browning. Therefore, its …

Diabetes is one of the major diseases worldwide and is the third leading cause of death in
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …

Hyperpigmentation is a common and distressing dermatologic condition. Since tyrosinase
(TYR) plays an essential role in melanogenesis, its inhibition is considered a logical …

Tyrosinase is a copper-containing oxidation enzyme, which is responsible for the production
of melanin. This enzyme is widely distributed in microorganisms, animals and plants, and …

Abstract Novel series of 5-benzylidenethiazolidine-2, 4-dione derivatives 4 ac-8 af were
designed, synthesized and evaluated for anticancer activity against HepG2, HCT-116 and …

The promising activity shown by compounds containing thiazolidine-2, 4-dione nucleus in
numerous categories such as anti-hyperglycaemics, aldose reductase inhibitors, anti …

A variety of substituents on the thiazolidine-2, 4-dione (TZD) nucleus have provided a wide
spectrum of biological activities by the using of different mechanism on various target sites …

The anticancer activity of novel thiazolidine‐2, 4‐diones was evaluated against HepG2, HCT‐
116, and MCF‐7 cells. MCF‐7 was the most sensitive cell line to the cytotoxicity of the new …

Thiazolidinedione is an important heterocyclic ring system, a pharmacophore and a
privileged scaffold in medicinal chemistry; is a derivative of thiazolidine ring which came into …

Biocompatible fluorescent reporters with spectral properties spanning the entire visible
spectrum are indispensable tools for imaging the biochemistry of living cells and organisms …