Aim This clinical practice guideline for the evaluation and diagnosis of chest pain provides
recommendations and algorithms for clinicians to assess and diagnose chest pain in adult …

Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

Abstract The 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart
Failure Treatment was created to provide a practical, streamlined resource for clinicians …

MicroRNAs (miRNAs) are small regulatory molecules post-transcriptionally suppressing
mRNA activity. Many miRNAs in various organisms have been cloned but many unknown …

Background Ischemic heart disease (IHD) is a leading cause of death worldwide. Also
referred to as coronary artery disease (CAD) and atherosclerotic cardiovascular disease …

Abstract Background Coronary Artery Disease (CAD) is the foremost single cause of
mortality and loss of Disability Adjusted Life Years (DALYs) globally. A large percentage of …

One of the most important causes of neurological morbidity and mortality in the world is
ischemic stroke. It can be a result of multiple events such as embolism with a cardiac origin …

Feature attributions based on the Shapley value are popular for explaining machine
learning models. However, their estimation is complex from both theoretical and …

Cell death is an essential feature of development in multicellular organisms, a critical driver
of degenerative diseases, and can be harnessed for treating some cancers. Understanding …

Tree-based machine learning models such as random forests, decision trees and gradient
boosted trees are popular nonlinear predictive models, yet comparatively little attention has …