Cardiac energy metabolism in heart failure

GD Lopaschuk, QG Karwi, R Tian, AR Wende… - Circulation …, 2021 - Am Heart Assoc
Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

Algorithms to estimate Shapley value feature attributions

H Chen, IC Covert, SM Lundberg, SI Lee - Nature Machine Intelligence, 2023 - nature.com
Feature attributions based on the Shapley value are popular for explaining machine
learning models. However, their estimation is complex from both theoretical and …

2021 update to the 2017 ACC expert consensus decision pathway for optimization of heart failure treatment: answers to 10 pivotal issues about heart failure with …

TM Maddox, JL Januzzi Jr, LA Allen, K Breathett… - Journal of the American …, 2021 - jacc.org
2021 Update to the 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart
Failure Treatment: Answers to 10 Pivotal Issues About Heart Failure With Reduced Ejection …

[HTML][HTML] Global epidemiology of ischemic heart disease: results from the global burden of disease study

MAB Khan, MJ Hashim, H Mustafa, MY Baniyas… - Cureus, 2020 - ncbi.nlm.nih.gov
Background Ischemic heart disease (IHD) is a leading cause of death worldwide. Also
referred to as coronary artery disease (CAD) and atherosclerotic cardiovascular disease …

Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches

CD Maida, RL Norrito, M Daidone… - International journal of …, 2020 - mdpi.com
One of the most important causes of neurological morbidity and mortality in the world is
ischemic stroke. It can be a result of multiple events such as embolism with a cardiac origin …

From local explanations to global understanding with explainable AI for trees

SM Lundberg, G Erion, H Chen, A DeGrave… - Nature machine …, 2020 - nature.com
Tree-based machine learning models such as random forests, decision trees and gradient
boosted trees are popular nonlinear predictive models, yet comparatively little attention has …

Pathophysiology and treatment of stroke: present status and future perspectives

D Kuriakose, Z Xiao - International journal of molecular sciences, 2020 - mdpi.com
Stroke is the second leading cause of death and a major contributor to disability worldwide.
The prevalence of stroke is highest in developing countries, with ischemic stroke being the …

Loss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-mediated ferroptosis

X Fang, Z Cai, H Wang, D Han, Q Cheng… - Circulation …, 2020 - Am Heart Assoc
Rationale: Maintaining iron homeostasis is essential for proper cardiac function. Both iron
deficiency and iron overload are associated with cardiomyopathy and heart failure via …

Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell

T Bai, M Li, Y Liu, Z Qiao, Z Wang - Free Radical Biology and Medicine, 2020 - Elsevier
Atherosclerosis (AS) is the fundamental pathological state of many serious vascular
diseases, characterized by disorders of lipid metabolism. Ferroptosis is a type of regulated …

[HTML][HTML] Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

S Lyu, Z Dong, X Xu, HP Bei, HY Yuen, CWJ Cheung… - Bioactive materials, 2023 - Elsevier
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its
non-invasiveness, painless and simple administration, controllable drug delivery, and …