Design, synthesis and anticancer activity of novel nopinone-based thiosemicarbazone derivatives
Y Wang, W Gu, Y Shan, F Liu, X Xu, Y Yang… - Bioorganic & Medicinal …, 2017 - Elsevier
A series of new nopinone-based thiosemicarbazone derivatives were designed and
synthesized as potent anticancer agents. All these compounds were identified by 1 H NMR …
synthesized as potent anticancer agents. All these compounds were identified by 1 H NMR …
Synthesis, characterization, photoluminescence properties and cytotoxic activities of Sm (III) complexes of β-diketones
AO Sarıoğlu, DT Kahraman, A Köse… - Journal of Molecular …, 2022 - Elsevier
Three new homoleptic six-coordinate Sm (III) complexes have been synthesized from β-
diketone ligand with different substituent groups. The structural characterization of these …
diketone ligand with different substituent groups. The structural characterization of these …
[HTML][HTML] Synthesis and evaluation of new benzodioxole-based thiosemicarbazone derivatives as potential antitumor agents
New benzodioxole-based thiosemicarbazone derivatives were synthesized and evaluated
for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 …
for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 …
Synthesis of Novel Chiral Sulfonamide‐Bearing 1,2,4‐Triazole‐3‐thione Analogs Derived from D‐ and L‐Phenylalanine Esters as Potential Anti‐Influenza Agents
E Başaran, A Karaküçük‐Iyidoğan, D Schols… - Chirality, 2016 - Wiley Online Library
Abstract Novel enantiopure 1, 2, 4‐trizole‐3‐thiones containing a benzensulfonamide
moiety were synthesized via multistep reaction sequence starting with D‐phenylalanine …
moiety were synthesized via multistep reaction sequence starting with D‐phenylalanine …
A novel fluorinated thiosemicarbazone derivative-2-(3, 4-difluorobenzylidene) hydrazinecarbothioamide induces apoptosis in human A549 lung cancer cells via ROS …
Y Zhao, C Guo, L Wang, S Wang, X Li, B Jiang… - Biochemical and …, 2017 - Elsevier
Thiosemicarbazone, a class of compounds with excellent biological activity, especially
antitumor activity, have attracted wide attention. In this study, a novel fluorinated …
antitumor activity, have attracted wide attention. In this study, a novel fluorinated …
Development of new chiral 1, 2, 4-triazole-3-thiones and 1, 3, 4-thiadiazoles with promising in vivo anticonvulsant activity targeting GABAergic system and voltage …
Antiepileptic drugs (AEDs) are used in the treatment of epilepsy, a neurodegenerative
disease characterized by recurrent and untriggered seizures that aim to prevent seizures as …
disease characterized by recurrent and untriggered seizures that aim to prevent seizures as …
Discovery of new chiral sulfonamides bearing benzoxadiazole as HIF inhibitors for non-small cell lung cancer therapy: design, microwave-assisted synthesis, binding …
DT Kahraman, A Karaküçük-İyidoğan… - New Journal of …, 2022 - pubs.rsc.org
Hypoxia-inducible factors (HIF) are among the targeted treatment strategies with increasing
promise in lung cancer, and are known to play a role in tumour growth and other oncogenic …
promise in lung cancer, and are known to play a role in tumour growth and other oncogenic …
Synthesis and anticancer activities of thiosemicarbazones derivatives of thiochromanones and related scaffolds
J Song, R Pan, G Li, W Su, X Song, J Li… - Medicinal Chemistry …, 2020 - Springer
A series of novel thiosemicarbazone analogs (4a–t, 6a–j) were synthesized and evaluated
for their cytotoxic activities. The obtained results showed that thiochromanone-based …
for their cytotoxic activities. The obtained results showed that thiochromanone-based …
Chiral thioureas containing naphthalene moiety as selective butyrylcholinesterase inhibitors: Design, synthesis, cholinesterase inhibition activity and molecular …
A Karaküçük-İyidoğan, Y Sıcak, DB Uysal… - Journal of Molecular …, 2025 - Elsevier
Butyrylcholinesterase (BChE), which plays a role in the regulation of acetylcholine (ACh) as
well as cholinergic type neurotransmission, also has non-cholinergic functions such as …
well as cholinergic type neurotransmission, also has non-cholinergic functions such as …
Metal complexes of thiosemicarbazones as potent anticancer agents: a minireview
Y Zhao, L Wang, C Guo, B Jiang, X Li… - Medicine …, 2018 - medicineresearch.org
As cancer is one of humanity's biggest killers in the world, scientists have been looking for
different drugs as agents to treat cancer. However, current chemotherapeutics is not …
different drugs as agents to treat cancer. However, current chemotherapeutics is not …