[HTML][HTML] The physical microenvironment of hematopoietic stem cells and its emerging roles in engineering applications

P Zhang, C Zhang, J Li, J Han, X Liu… - Stem Cell Research & …, 2019 - Springer
Stem cells are considered the fundamental underpinnings of tissue biology. The stem cell
microenvironment provides factors and elements that play significant roles in controlling the …

[HTML][HTML] Bone marrow niches of hematopoietic stem and progenitor cells

O Kandarakov, A Belyavsky, E Semenova - International Journal of …, 2022 - mdpi.com
The mammalian hematopoietic system is remarkably efficient in meeting an organism's vital
needs, yet is highly sensitive and exquisitely regulated. Much of the organismal control over …

[HTML][HTML] Current insights into the bone marrow niche: From biology in vivo to bioengineering ex vivo

Y Xiao, CAS McGuinness, WS Doherty-Boyd… - Biomaterials, 2022 - Elsevier
Hematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and
immune cells. They reside primarily within the bone marrow (BM) niche microenvironment …

In vitro expansion of hematopoietic stem cells in a porous hydrogel-based 3D culture system

B Liu, M Jin, DA Wang - Acta Biomaterialia, 2023 - Elsevier
Hematopoietic stem cell (HSC) transplantation remains the most effective therapy for
hematologic and lymphoid disorders. However, as the primary therapeutic cells, the source …

[HTML][HTML] Current status and future prospects of perinatal stem cells

P Torre, AI Flores - Genes, 2020 - mdpi.com
The placenta is a temporary organ that is discarded after birth and is one of the most
promising sources of various cells and tissues for use in regenerative medicine and tissue …

[HTML][HTML] The spatiotemporal heterogeneity of the biophysical microenvironment during hematopoietic stem cell development: from embryo to adult

G Shi, P Zhang, X Zhang, J Li, X Zheng, J Yan… - Stem Cell Research & …, 2023 - Springer
Hematopoietic stem cells (HSCs) with the ability to self-renew and differentiate are
responsible for maintaining the supply of all types of blood cells. The complex and delicate …

[HTML][HTML] Biomechanical cues as master regulators of hematopoietic stem cell fate

H Li, Q Luo, W Shan, S Cai, R Tie, Y Xu, Y Lin… - Cellular and Molecular …, 2021 - Springer
Hematopoietic stem cells (HSCs) perceive both soluble signals and biomechanical inputs
from their microenvironment and cells themselves. Emerging as critical regulators of the …

Umbilical cord stem cells: Background, processing and applications

SM Alatyyat, HM Alasmari, OA Aleid… - Tissue and Cell, 2020 - Elsevier
Stem cells have currently gained attention in the field of medicine not only due to their ability
to repair dysfunctional or damaged cells, but also they could be used as drug delivery …

Biophysical cues of bone marrow-inspired scaffolds regulate hematopoiesis of hematopoietic stem and progenitor cells

W Li, H Liang, Y Ao, B Tang, J Li, N Li, J Wang, Y Du - Biomaterials, 2023 - Elsevier
Hematopoietic stem cells (HSCs) are adult multipotential stem cells with the capacity to
differentiate into all blood cells and immune cells, which are essential for maintaining …

Biomaterial-assisted scalable cell production for cell therapy

R Chen, L Li, L Feng, Y Luo, M Xu, KW Leong, R Yao - Biomaterials, 2020 - Elsevier
Cell therapy, the treatment of diseases using living cells, offers a promising clinical approach
to treating refractory diseases. The global market for cell therapy is growing rapidly, and …