Aplastic anemia, cellular and molecular aspects

MR Javan, N Saki… - Cell Biology …, 2021 - Wiley Online Library
Aplastic anemia (AA) is an autoimmune disorder characterized by bone marrow and
peripheral blood pancytopenia. Different environmental and genetical conditions could be …

[HTML][HTML] Aplastic anemia as a roadmap for bone marrow failure: an overview and a clinical workflow

AG Solimando, C Palumbo, MV Pragnell… - International Journal of …, 2022 - mdpi.com
In recent years, it has become increasingly apparent that bone marrow (BM) failures and
myeloid malignancy predisposition syndromes are characterized by a wide phenotypic …

[HTML][HTML] Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia

S Lundgren, MAI Keränen, M Kankainen, J Huuhtanen… - Leukemia, 2021 - nature.com
The prevalence and functional impact of somatic mutations in nonleukemic T cells is not well
characterized, although clonal T-cell expansions are common. In immune-mediated aplastic …

[HTML][HTML] Genome-wide association study identifies HLA-DPB1 as a significant risk factor for severe aplastic anemia

SA Savage, M Viard, C O'huigin, W Zhou… - The American Journal of …, 2020 - cell.com
Severe aplastic anemia (SAA) is a rare disorder characterized by hypoplastic bone marrow
and progressive pancytopenia. The etiology of acquired SAA is not understood but is likely …

Increased IFN‐γ+ and TNF‐α+ mucosal‐associated invariant T cells in patients with aplastic anemia

X Chen, Y Zhang, Y Zhang, Y Zhang… - Cytometry Part B …, 2023 - Wiley Online Library
Background Aplastic anemia (AA) is known as an autoimmune disease in which T cell
activation is aberrant. It has been reported that unconventional T cells, mucosal‐associated …

[HTML][HTML] Regulatory γδ T cells induced by G-CSF participate in acute graft-versus-host disease regulation in G-CSF-mobilized allogeneic peripheral blood stem cell …

L Xuan, X Wu, D Qiu, L Gao, H Liu, Z Fan… - Journal of Translational …, 2018 - Springer
Background The immunomodulatory effects of granulocyte colony-stimulating factor (G-CSF)
on T cells result in a low incidence of acute graft-versus-host disease (aGVHD) in G-CSF …

[HTML][HTML] Yin and Yang of mesenchymal stem cells and aplastic anemia

L Broglie, D Margolis, JA Medin - World Journal of Stem Cells, 2017 - ncbi.nlm.nih.gov
Acquired aplastic anemia (AA) is a bone marrow failure syndrome characterized by
peripheral cytopenias and bone marrow hypoplasia. It is ultimately fatal without treatment …

[HTML][HTML] Aplastic anemia is related to alterations in T cell receptor signaling

Y Xiao, S Zhao, B Li - Stem cell investigation, 2017 - ncbi.nlm.nih.gov
Aplastic anemia (AA) is a disease characterized by bone marrow hematopoietic dysfunction
and peripheral blood pancytopenia, which is thought to be mediated by an abnormal T cell …

Increased CD8+ CD27+ perforin+ T cells and decreased CD8+ CD70+ T cells may be immune biomarkers for aplastic anemia severity

S Zhao, Y Zhang, G Huang, W Luo, Y Li, Y Xiao… - Blood Cells, Molecules …, 2019 - Elsevier
Objectives Aplastic anemia (AA) is T cell immune-mediated autoimmune disease. Aberrant T
cell activation involves an imbalance in T cell homeostasis in AA. However, whether the T …

[HTML][HTML] Anti-Thymocyte Globulin (ATG)-Free Nonmyeloablative Haploidentical PBSCT Plus Post-Transplantation Cyclophosphamide Is a Safe and Efficient Treatment …

RL Chen, PP Ip, J Shaw, YH Wang, LH Fan… - International Journal of …, 2022 - mdpi.com
Most cases of acquired aplastic anemia (AA) arise from autoimmune destruction of
hematopoietic stem and progenitor cells. Human leukocyte antigen (HLA)-haploidentical …