New Findings What is the topic of this review? The manuscript collectively combines the
experimental observations from> 100 publications focusing on the regulation of cerebral …

Molecular oxygen (O2) is a vital element in human survival and plays a major role in a
diverse range of biological and physiological processes. Although normobaric hyperoxia …

People undertaking prolonged vigorous exercise experience substantial bodily fluid losses
due to thermoregulatory sweating. If these fluid losses are not replaced, endurance capacity …

New Findings What is the topic of this review? Cerebrovascular reactivity to CO2, which is a
principal factor in determining ventilatory responses to CO2 through the role reactivity plays …

Blood velocity measured in the middle cerebral artery (MCAV) increases with finite kinetics
during moderate-intensity exercise, and the amplitude and dynamics of the response …

The mechanistic role of arterial shear stress in the regulation of cerebrovascular responses
to physiological stimuli (exercise and hypercapnia) is poorly understood. We hypothesised …

The first accounts of measuring cerebral blood flow (CBF) in humans were made by Angelo
Mosso in~ 1880, who recorded brain pulsations in patients with skull defects. In 1890 …

Background Acute exercise performance can be limited by arterial hypoxemia, such that
hyperoxia may be an ergogenic aid by increasing tissue oxygen availability. Hyperoxia …

Purpose: Cognitive performance appears to be impaired during high-intensity exercise, and
this occurs concurrently with a reduction in cerebral blood flow (CBF). However, it is unclear …

New Findings What is the central question of this study? Do differing magnitudes of
ventilation influence cerebrovascular CO2 reactivity and the cerebral blood flow response to …