The long journey of cancer biomarkers from the bench to the clinic

MP Pavlou, EP Diamandis, IM Blasutig - Clinical chemistry, 2013 - academic.oup.com
BACKGROUND Protein cancer biomarkers serve multiple clinical purposes, both early and
late, during disease progression. The search for new and better biomarkers has become an …

Biomarkers for prostate cancer

DV Makarov, S Loeb, RH Getzenberg… - Annual review of …, 2009 - annualreviews.org
The development of biomarkers for prostate cancer screening, detection, and
prognostication has revolutionized the management of this disease. Prostate-specific …

Cancer biomarkers: can we turn recent failures into success?

EP Diamandis - Journal of the National Cancer Institute, 2010 - academic.oup.com
Disease biomarkers are used widely in medicine. But very few biomarkers are useful for
cancer diagnosis and monitoring. Over the past 15 years, major investments have been …

Predicting detection limits of enzyme-linked immunosorbent assay (ELISA) and bioanalytical techniques in general

S Zhang, A Garcia-D'Angeli, JP Brennan, Q Huo - Analyst, 2014 - pubs.rsc.org
The detection limit is one of the most important performance parameters for bioanalytical
techniques. Here we present a generic method to estimate the detection limit of …

Urinary volatile organic compounds for the detection of prostate cancer

T Khalid, R Aggio, P White, B De Lacy Costello… - PloS one, 2015 - journals.plos.org
The aim of this work was to investigate volatile organic compounds (VOCs) emanating from
urine samples to determine whether they can be used to classify samples into those from …

Emerging biomarkers for the diagnosis and prognosis of prostate cancer

G Sardana, B Dowell, EP Diamandis - Clinical chemistry, 2008 - academic.oup.com
Background: Early detection of prostate cancer (CaP), the most prevalent cancer and the
second-leading cause of death in men, has proved difficult, and current detection methods …

Prostate cancer biomarkers: an update

JR Otero, BG Gomez, FC Juanatey… - … Oncology: Seminars and …, 2014 - Elsevier
Many aspects of prostate cancer diagnosis and treatment could be greatly advanced with
new, effective biomarkers. Prostate-specific antigen (PSA) has multiple weaknesses as a …

Annexin A3 in urine: a highly specific noninvasive marker for prostate cancer early detection

M Schostak, GP Schwall, S Poznanović… - The Journal of …, 2009 - auajournals.org
Purpose: In prostate cancer cases the early diagnosis of tumors carrying a high risk of
progression is of the utmost importance. There is an urgent clinical need to avoid …

The present and future of prostate cancer urine biomarkers

M Rigau, M Olivan, M Garcia, T Sequeiros… - International journal of …, 2013 - mdpi.com
In order to successfully cure patients with prostate cancer (PCa), it is important to detect the
disease at an early stage. The existing clinical biomarkers for PCa are not ideal, since they …

Evaluation of serum-based cancer biomarkers: a brief review from a clinical and computational viewpoint

S Yotsukura, H Mamitsuka - Critical reviews in oncology/hematology, 2015 - Elsevier
Biomarkers are vital to detect diseases in various clinical stages. A variety of cancer serum
biomarkers are already known, while for more accurate cancer-type detection, there …