Staphylococcus epidermidis and its dual lifestyle in skin health and infection

MM Severn, AR Horswill - Nature Reviews Microbiology, 2023 - nature.com
The coagulase-negative bacterium Staphylococcus epidermidis is a member of the human
skin microbiota. S. epidermidis is not merely a passive resident on skin but actively primes …

[HTML][HTML] The human skin microbiome

AL Byrd, Y Belkaid, JA Segre - Nature Reviews Microbiology, 2018 - nature.com
Functioning as the exterior interface of the human body with the environment, skin acts as a
physical barrier to prevent the invasion of foreign pathogens while providing a home to the …

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

MG Constantinides, VM Link, S Tamoutounour… - Science, 2019 - science.org
INTRODUCTION The microbiota promotes the maturation and homeostasis of the immune
system, in part through the release of microbial products. Early-life microbial colonization …

Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis

AL Byrd, C Deming, SKB Cassidy… - Science translational …, 2017 - science.org
The heterogeneous course, severity, and treatment responses among patients with atopic
dermatitis (AD; eczema) highlight the complexity of this multifactorial disease. Prior studies …

[PDF][PDF] Non-classical immunity controls microbiota impact on skin immunity and tissue repair

JL Linehan, OJ Harrison, SJ Han, AL Byrd… - Cell, 2018 - cell.com
Mammalian barrier surfaces are constitutively colonized by numerous microorganisms. We
explored how the microbiota was sensed by the immune system and the defining properties …

Staphylococcus epidermidis—Skin friend or foe?

MM Brown, AR Horswill - PLoS pathogens, 2020 - journals.plos.org
Author summary Our skin is our first line of defense against environmental and pathogenic
challenges. It is densely populated by a flora of bacteria, fungi, and viruses that normally …

[PDF][PDF] Temporal stability of the human skin microbiome

J Oh, AL Byrd, M Park, HH Kong, JA Segre - Cell, 2016 - cell.com
Biogeography and individuality shape the structural and functional composition of the
human skin microbiome. To explore these factors' contribution to skin microbial community …

Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury

OJ Harrison, JL Linehan, HY Shih, N Bouladoux… - Science, 2019 - science.org
INTRODUCTION Barrier tissues are constitutive targets of environmental stressors and are
home to a highly diverse microbiota. When the immune system encounters these …

Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

S Naik, N Bouladoux, JL Linehan, SJ Han, OJ Harrison… - Nature, 2015 - nature.com
The skin represents the primary interface between the host and the environment. This organ
is also home to trillions of microorganisms that play an important role in tissue homeostasis …

[HTML][HTML] Are coagulase-negative staphylococci virulent?

C Heilmann, W Ziebuhr, K Becker - Clinical Microbiology and Infection, 2019 - Elsevier
Background Progress in contemporary medicine is associated with an increasing number of
immunocompromised individuals. In this vulnerable group, the underlying disease together …