Ionizing radiation is frequently used to treat solid tumors, as it causes DNA damage and kill
cancer cells. However, damaged DNA is repaired involving poly-(ADP-ribose) polymerase-1 …

Quiescent cancer cells (QCCs) are nonproliferating cells arrested in the G0 phase,
characterized by ki67low and p27high. QCCs avoid most chemotherapies, and some …

Transcriptional deregulation is a hallmark of many cancers and is exemplified by genomic
amplifications of the MYC family of oncogenes, which occur in at least 20% of all solid …

Considering the fundamental role of protein kinases in the mechanism of protein
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …

Background Despite aggressive local and regional therapy, triple-negative breast cancer
(TNBC) is characterized by an increased risk of locoregional recurrence. RNA-sequencing …

Breast cancer (BC) is a common malignancy in women, with hormone receptor (HR)-positive
subtype responsible for approximately 70% of cases. Currently, patients with metastatic HR …

To improve wound healing or treatment of other skin diseases, and provide model cells for
skin biology studies, in vitro differentiation of stem cells into keratinocyte-like cells (KLCs) is …

In the current study, novel pyrazolo [3, 4-d] pyrimidine derivatives 5a–h were designed and
synthesized as targeted anti-cancer agents through dual CDK2/GSK-3β inhibition. The …

Aberrant cyclin-dependent kinase 2 (CDK2) activation has been identified as a main
resistance mechanism to CDK4/6 inhibition in hormone-positive (HR+) breast cancer …

Hepatocellular carcinoma (HCC) is one of the most common cancerous tumors and one of
the leading causes of death among cancer-related disorders. Chemotherapy is ineffective in …