Proteinase-activated receptors are a recently described, novel family of seven-
transmembrane G-protein-coupled receptors. Rather then being stimulated through ligand …

The action of thrombin is central to the processes of thrombosis and haemostasis (1).
Thrombin exhibits both enzymatic and hormone-like properties, that can be both pro-and …

A DNA sequence encoding a G-protein-coupled receptor was isolated from a mouse
genomic library. The predicted protein is similar in structure to the thrombin receptor and has …

Mitogen-activated protein kinases (p42mapk and p44mapk) are serine/threonine kinases
that are activated rapidly in cells stimulated with various extracellular signals. This activation …

Although it has been known since the 1960s that trypsin and chymotrypsin can mimic
hormone action in tissues, it took until the 1990s to discover that serine proteinases can …

We previously reported the molecular cloning of a mouse guanosine‐nucleotide‐binding‐
protein‐coupled receptor similar to the thrombin receptor. Since the physiological agonist …

Thrombin has been implicated in the stimulation of smooth muscle cell (SMC) proliferation
that contributes to post angioplasty restenosis. The present studies demonstrated that …

The human platelet thrombin receptor is activated when thrombin cleaves its receptor's
amino-terminal extension to reveal a new amino terminus that functions as a tethered …

Thrombin is a multifunctional serine protease generated at sites of vascular injury. A host of
thrombin actions on vascular endothelial cells, smooth muscle cells, and macrophages has …

Rap1 is a small Ras‐related GTPase which when over‐expressed is able to revert
transformation by Ki‐Ras. We have investigated the role of Rap1 in regulating 'normal'Ras …