Stem cell niches are composed of dynamic microenvironments that support stem cells over a
lifetime. The emerging niche is distinct from the adult because its main role is to support the …

Striated muscle is a highly plastic and regenerative organ that regulates body movement,
temperature, and metabolism—all the functions needed for an individual's health and well …

Critical-sized bone defects often lead to non-union and full-thickness defects of the
calvarium specifically still present reconstructive challenges. In this study, we show that …

Duchenne muscular dystrophy (DMD) is a fatal muscle disorder characterized by cycles of
degeneration and regeneration of multinucleated myofibers and pathological activation of a …

Rhabdomyosarcoma (RMS) is a common childhood cancer that shares features with
developing skeletal muscle. Yet, the conservation of cellular hierarchy with human muscle …

Despite breakthroughs in cancer immunotherapy, most tumor-reactive T cells cannot persist
in solid tumors due to an immunosuppressive environment. We developed Tres (tumor …

Rhabdomyosarcoma (RMS) is a group of pediatric cancers with features of developing
skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest …

Skeletal muscle stem and progenitor cells including those derived from human pluripotent
stem cells (hPSCs) offer an avenue towards personalized therapies and readily fuse to form …

Cultured meat production has emerged as a breakthrough technology for the global food
industry with the potential to reduce challenges associated with environmental sustainability …

Human skeletal stem cells (SSCs) have been discovered in fetal and adult long bones.
However, the spatiotemporal ontogeny of human embryonic SSCs during early …