Traumatic brain injury (TBI) is a major public health burden, causing death and disability
worldwide. Intracranial hypertension and brain hypoxia are the main mechanisms of …

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Despite
extensive research efforts, the majority of trialed monotherapies to date have failed to …

OBJECTIVE Severe traumatic brain injury (TBI) is a leading cause of disability and death in
the pediatric population. While intracranial pressure (ICP) monitoring is the gold standard in …

Mitochondrial dysfunction and the use of alternative energy substrates are potential
therapeutic targets, but improved understanding of the causes, impact and significance of …

Cerebral oxygenation represents the balance between oxygen delivery, consumption and
utilization by the brain, and therefore reflects the adequacy of cerebral perfusion. Different …

Invasive neuromonitoring has become an important part of pediatric neurocritical care, as
neuromonitoring devices provide objective data that can guide patient management in real …

Abstract Background Traumatic brain injuries (TBIs) are one of the leading causes of death
or long‐term disability around the world. As a result of improvements in supportive care …

Background Although the optimization of brain oxygenation is thought to improve the
prognosis, the effect of brain tissue oxygen pressure (PbtO2) for patients with severe …

To assess whether monitoring brain tissue oxygen partial pressure (PbtO2) or employing
intracranial pressure (ICP)/cerebral perfusion pressure (CCP)-guided management …

Monitoring intracranial pressure (ICP) is pivotal in the management of severe traumatic brain
injury (TBI), but secondary brain injuries can arise despite normal ICP levels. Cerebral tissue …