Actinoporins (APs) from sea anemones are~ 20 kDa pore forming toxins with a β-sandwich
structure flanked by two α-helices. The molecular mechanism of APs pore formation is …

Pore forming proteins (PFPs) share the ability of creating pores that allow the passage of
ions, proteins or other constituents through a wide variety of target membranes, ranging from …

Pore-forming protein toxins (PFTs) represent a diverse class of membrane-damaging
proteins that are produced by a wide variety of organisms. PFT-mediated membrane …

Highlights•PFPs are fundamental defense and virulence factors in bacteria and as executors
of regulated cell death in eukaryotic cells.•Proteins and lipids cooperate to form different …

Vaccine strategies to enhance CD8+ CTL responses remain a current challenge because
they should overcome the plasmatic and endosomal membranes for favoring exogenous Ag …

Sea anemone actinoporins constitute a protein family of multigene pore-forming toxins
(PFT). Equinatoxin II (EqtII), fragaceatoxin C (FraC), and sticholysins I and II (StnI and StnII …

Actinoporins constitute a unique class of pore-forming toxins found in sea anemones that
are able to bind and oligomerize in membranes, leading to cell swelling, impairment of ionic …

Sticholysins are α-pore-forming toxins produced by the sea-anemone Stichodactyla
helianthus. These toxins exert their activity by forming pores on sphingomyelin-containing …

Sticholysins are pore-forming toxins of biomedical interest and represent a prototype of
proteins acting through the formation of protein-lipid or toroidal pores. Peptides spanning the …

Sticholysin II (StnII) is a pore-forming toxin that uses sphingomyelin (SM) as the recognition
molecule in targeting membranes. After StnII monomers bind to SM, several toxin monomers …