NETosis: molecular mechanisms, role in physiology and pathology
NV Vorobjeva, BV Chernyak - Biochemistry (Moscow), 2020 - Springer
NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of
modified chromatin decorated with bactericidal proteins from granules and cytoplasm …
modified chromatin decorated with bactericidal proteins from granules and cytoplasm …
Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …
Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens
AJ Monteith, JM Miller, CN Maxwell, WJ Chazin… - Science …, 2021 - science.org
Neutrophils and macrophages are critical to the innate immune response, but cooperative
mechanisms used by these cells to combat extracellular pathogens are not well understood …
mechanisms used by these cells to combat extracellular pathogens are not well understood …
The vitals of NETs
Neutrophils produce neutrophil extracellular traps (NETs) by expelling their extracellular
chromatin embedded with citrullinated histone H3, myeloperoxidase, and other intracellular …
chromatin embedded with citrullinated histone H3, myeloperoxidase, and other intracellular …
[HTML][HTML] MLKL: Functions beyond serving as the Executioner of Necroptosis
Recently, necroptosis, as a programmed cell death pathway, has drawn much attention as it
has been implicated in multiple pathologies, especially in the field of inflammatory diseases …
has been implicated in multiple pathologies, especially in the field of inflammatory diseases …
Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction
J Novotny, P Oberdieck, A Titova, J Pelisek… - Neurology, 2020 - AAN Enterprises
Objective To investigate whether immune cell composition and content of neutrophil
extracellular traps (NETs) in relation to clinical outcome are different between acute …
extracellular traps (NETs) in relation to clinical outcome are different between acute …
Neutrophil extracellular traps: a potential therapeutic target in MPO-ANCA associated vasculitis?
KM O'Sullivan, SR Holdsworth - Frontiers in immunology, 2021 - frontiersin.org
Our understanding of immune recognition and response to infection and non-infectious
forms of cell damage and death is rapidly increasing. The major focus is on host immunity …
forms of cell damage and death is rapidly increasing. The major focus is on host immunity …
Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C
BACKGROUND Multisystem inflammatory syndrome in children (MIS-C) is a rare but
potentially severe illness that follows exposure to severe acute respiratory syndrome …
potentially severe illness that follows exposure to severe acute respiratory syndrome …
NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils
Neutrophil extracellular traps (NETs) not only counteract bacterial and fungal pathogens but
can also promote thrombosis, autoimmunity, and sterile inflammation. The presence of …
can also promote thrombosis, autoimmunity, and sterile inflammation. The presence of …
NET formation–mechanisms and how they relate to other cell death pathways
T Rosazza, J Warner, G Sollberger - The FEBS journal, 2021 - Wiley Online Library
Cell death is an integral part of both infectious and sterile inflammatory reactions. Many cell
death pathways cause the dying cell to lyse, thereby amplifying inflammation. A special form …
death pathways cause the dying cell to lyse, thereby amplifying inflammation. A special form …