NETosis: molecular mechanisms, role in physiology and pathology

NV Vorobjeva, BV Chernyak - Biochemistry (Moscow), 2020 - Springer
NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of
modified chromatin decorated with bactericidal proteins from granules and cytoplasm …

Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target

L Mifflin, D Ofengeim, J Yuan - Nature reviews Drug discovery, 2020 - nature.com
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …

Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens

AJ Monteith, JM Miller, CN Maxwell, WJ Chazin… - Science …, 2021 - science.org
Neutrophils and macrophages are critical to the innate immune response, but cooperative
mechanisms used by these cells to combat extracellular pathogens are not well understood …

The vitals of NETs

C Tan, M Aziz, P Wang - Journal of leukocyte biology, 2021 - academic.oup.com
Neutrophils produce neutrophil extracellular traps (NETs) by expelling their extracellular
chromatin embedded with citrullinated histone H3, myeloperoxidase, and other intracellular …

[HTML][HTML] MLKL: Functions beyond serving as the Executioner of Necroptosis

C Zhan, M Huang, X Yang, J Hou - Theranostics, 2021 - ncbi.nlm.nih.gov
Recently, necroptosis, as a programmed cell death pathway, has drawn much attention as it
has been implicated in multiple pathologies, especially in the field of inflammatory diseases …

Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction

J Novotny, P Oberdieck, A Titova, J Pelisek… - Neurology, 2020 - AAN Enterprises
Objective To investigate whether immune cell composition and content of neutrophil
extracellular traps (NETs) in relation to clinical outcome are different between acute …

Neutrophil extracellular traps: a potential therapeutic target in MPO-ANCA associated vasculitis?

KM O'Sullivan, SR Holdsworth - Frontiers in immunology, 2021 - frontiersin.org
Our understanding of immune recognition and response to infection and non-infectious
forms of cell damage and death is rapidly increasing. The major focus is on host immunity …

Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C

YP Zhu, I Shamie, JC Lee, CJ Nowell… - The Journal of …, 2021 - Am Soc Clin Investig
BACKGROUND Multisystem inflammatory syndrome in children (MIS-C) is a rare but
potentially severe illness that follows exposure to severe acute respiratory syndrome …

NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils

YP Zhu, M Speir, ZH Tan, JC Lee, CJ Nowell… - Science …, 2023 - science.org
Neutrophil extracellular traps (NETs) not only counteract bacterial and fungal pathogens but
can also promote thrombosis, autoimmunity, and sterile inflammation. The presence of …

NET formation–mechanisms and how they relate to other cell death pathways

T Rosazza, J Warner, G Sollberger - The FEBS journal, 2021 - Wiley Online Library
Cell death is an integral part of both infectious and sterile inflammatory reactions. Many cell
death pathways cause the dying cell to lyse, thereby amplifying inflammation. A special form …