Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Angiogenesis is a vital process for the growth and dissemination of solid cancers. Numerous
molecular pathways are known to drive angiogenic switch in cancer cells promoting the …

Metastatic disease is the primary cause of death for most cancer patients. Complex and
redundant pathways involving the tumor cell and the microenvironment mediate tumor …

Bone and bone marrow are among the most frequent metastatic sites of cancer. The
occurrence of bone metastasis is frequently associated with a dismal disease outcome. The …

Breast cancer is the most common cancer affecting women worldwide, with bone
metastases presenting as the most common site of disease recurrence. Bone metastases …

Angiogenesis in normal and pathological conditions is a multi-step process governed by
positive and negative endogenous regulators. Many growth factors are involved in different …

Introduction Studies in xenograft models and experimental models of metastasis have
implicated several β3 integrin-expressing cell populations, including endothelium, platelets …

Peripheral T cell lymphoma, unspecified (PTCL/U), the most common form of PTCL, displays
heterogeneous morphology and phenotype, poor response to treatment, and poor …

Signaling through platelet‐derived growth factor (PDGF) receptors contributes to multiple
tumor‐associated processes. The recent introduction of clinically useful PDGF inhibitors …

Background The non–receptor protein tyrosine, Src, is a 60-kDa protein that is the
archetypal member of a nine-gene family, including Src, Yes, Fyn, Lyn, Lck, Hck, Fgr, Blk …