The role of BCL-2 family proteins in regulating apoptosis and cancer therapy

S Qian, Z Wei, W Yang, J Huang, Y Yang… - Frontiers in …, 2022 - frontiersin.org
Apoptosis, as a very important biological process, is a response to developmental cues or
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …

The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders

S Zhang, X Peng, S Yang, X Li, M Huang, S Wei… - Cell death & …, 2022 - nature.com
Autophagy is a conserved method of quality control in which cytoplasmic contents are
degraded via lysosomes. Lipophagy, a form of selective autophagy and a novel type of lipid …

Neuroinflammation in Alzheimer's disease

IG Onyango, GV Jauregui, M Čarná, JP Bennett Jr… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

[HTML][HTML] Role and regulation of autophagy in cancer

R Rakesh, LC PriyaDharshini, KM Sakthivel… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Autophagy is an intracellular self-degradative mechanism which responds to cellular
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …

Autophagy and skin wound healing

H Ren, F Zhao, Q Zhang, X Huang, Z Wang - Burns & trauma, 2022 - academic.oup.com
Autophagy is a lysosome-dependent, self-renewal mechanism that can degrade and recycle
cellular components in eukaryotic cells to maintain the stability of the intracellular …

Molecular mechanisms of neuroinflammation in aging and Alzheimer's disease progression

FL Andronie-Cioara, AI Ardelean… - International journal of …, 2023 - mdpi.com
Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …

The V-ATPases in cancer and cell death

F Chen, R Kang, J Liu, D Tang - Cancer gene therapy, 2022 - nature.com
Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …

Alzheimer's disease and inflammaging

AM Kosyreva, AV Sentyabreva, IS Tsvetkov… - Brain sciences, 2022 - mdpi.com
Alzheimer's disease is one of the most common age-related neurodegenerative disorders.
The main theory of Alzheimer's disease progress is the amyloid-β cascade hypothesis …

[HTML][HTML] Autophagy and renal fibrosis

S Liang, YS Wu, DY Li, JX Tang, HF Liu - Aging and disease, 2022 - ncbi.nlm.nih.gov
Renal fibrosis is a common process of almost all the chronic kidney diseases progressing to
end-stage kidney disease. As a highly conserved lysosomal protein degradation pathway …

SIRT1 and autophagy: implications in endocrine disorders

JY Kim, D Mondaca-Ruff, S Singh… - Frontiers in …, 2022 - frontiersin.org
Autophagy is a cellular process involved in the selective degradation and recycling of
dysfunctional intracellular components. It plays a crucial role in maintaining cellular …