Hemochorial placentation: development, function, and adaptations

MJ Soares, KM Varberg, K Iqbal - Biology of reproduction, 2018 - academic.oup.com
Placentation is a reproductive adaptation that permits fetal growth and development within
the protected confines of the female reproductive tract. Through this important role, the …

Single-cell RNA-seq identifies cell subsets in human placenta that highly expresses factors driving pathogenesis of SARS-CoV-2

N Ashary, A Bhide, P Chakraborty, S Colaco… - Frontiers in cell and …, 2020 - frontiersin.org
Infection by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) results in
the novel coronavirus disease COVID-19, which has posed a serious threat globally …

Single-nuclei RNA sequencing (snRNA-seq) uncovers trophoblast cell types and lineages in the mature bovine placenta

KM Davenport, MS Ortega, H Liu… - Proceedings of the …, 2023 - National Acad Sciences
Ruminants have a semi-invasive placenta, which possess highly vascularized placentomes
formed by maternal endometrial caruncles and fetal placental cotyledons and required for …

[HTML][HTML] The placenta goes viral: Retroviruses control gene expression in pregnancy

EB Chuong - PLoS biology, 2018 - journals.plos.org
The co-option of endogenous retroviruses (ERVs) is increasingly recognized as a recurrent
theme in placental biology, which has far-reaching implications for our understanding of …

Extant and extinct bilby genomes combined with Indigenous knowledge improve conservation of a unique Australian marsupial

CJ Hogg, RJ Edwards, KA Farquharson… - Nature Ecology & …, 2024 - nature.com
Ninu (greater bilby, Macrotis lagotis) are desert-dwelling, culturally and ecologically
important marsupials. In collaboration with Indigenous rangers and conservation managers …

Human endogenous retroviruses: our genomic fossils and companions

RA Stein, RV DePaola - Physiological Genomics, 2023 - journals.physiology.org
Approximately 8% of the human genome, over four times more than its protein-coding
regions, comprises sequences of viral origin that are known as human endogenous …

Placental secretome characterization identifies candidates for pregnancy complications

T Napso, X Zhao, MI Lligoña, I Sandovici… - Communications …, 2021 - nature.com
Alterations in maternal physiological adaptation during pregnancy lead to complications,
including abnormal birthweight and gestational diabetes. Maternal adaptations are driven by …

Evolutionary transcriptomics implicates HAND2 in the origins of implantation and regulation of gestation length

M Marinić, K Mika, S Chigurupati, VJ Lynch - Elife, 2021 - elifesciences.org
The developmental origins and evolutionary histories of cell types, tissues, and organs
contribute to the ways in which their dysfunction produces disease. In mammals, the nature …

Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes

K Mika, M Marinić, M Singh, J Muter, JJ Brosens… - Elife, 2021 - elifesciences.org
Evolutionary changes in the anatomy and physiology of the female reproductive system
underlie the origins and diversification of pregnancy in Eutherian ('placental') mammals. This …

Single-cell insights into development of the bovine placenta

KM Davenport, EV O'Neil, MS Ortega… - Biology of …, 2024 - academic.oup.com
A central determinant of pregnancy success is proper development of the conceptus
(embryo/fetus and associated extraembryonic membranes including the placenta). Although …