[HTML][HTML] Complex regulatory networks of virulence factors in Vibrio vulnificus

G Choi, SH Choi - Trends in Microbiology, 2022 - cell.com
The fulminating zoonotic pathogen Vibrio vulnificus is the causative agent of fatal septicemia
in humans and fish, raising tremendous economic burdens in healthcare and the …

Regulation systems of protease and hemolysin production in Vibrio vulnificus

A Elgaml, SI Miyoshi - Microbiology and Immunology, 2017 - Wiley Online Library
Vibrio vulnificus, a gram‐negative halophilic estuarine bacterium, is an opportunistic human
pathogen that causes rapidly progressive fatal septicemia and necrotizing wound infection …

[HTML][HTML] Amino acid–derived quorum sensing molecules controlling the virulence of vibrios (and beyond)

T Defoirdt - PLoS Pathogens, 2019 - journals.plos.org
Antibiotic-resistant bacteria are currently posing a major threat to our society, rendering
several human and animal infections hard to cure, and this situation is predicted to become …

Cyclo-(l-Phe-l-Pro), a Quorum-Sensing Signal of Vibrio vulnificus, Induces Expression of Hydroperoxidase through a ToxR-LeuO-HU-RpoS Signaling Pathway To …

IH Kim, SY Kim, NY Park, Y Wen, KW Lee… - Infection and …, 2018 - Am Soc Microbiol
Vibrio vulnificus, an opportunistic human pathogen, produces cyclo-(l-Phe-l-Pro)(cFP),
which serves as a signaling molecule controlling the ToxR-dependent expression of innate …

[HTML][HTML] Iron-Fur complex suppresses the expression of components of the cyclo-(Phe-Pro)-signaling regulatory pathway in Vibrio vulnificus

KW Lee, S Kim, S Lee, M Kim, S Song… - Frontiers in …, 2023 - frontiersin.org
In the human pathogen Vibrio vulnificus, the quorum-sensing (QS) signal molecule cyclo-(L-
phenylalanine-L-proline)(cFP) plays a critical role in triggering a signaling pathway involving …

[HTML][HTML] Multi-Factor Regulation of the Master Modulator LeuO for the Cyclic-(Phe-Pro) Signaling Pathway in Vibrio vulnificus

NY Park, IH Kim, Y Wen, KW Lee, S Lee, JA Kim… - Scientific Reports, 2019 - nature.com
LeuO plays the role of a master regulator in the cyclic-L-phenylalanine-L-proline (cFP)-
dependent signaling pathway in Vibrio vulnificus. cFP, as shown through isothermal titration …

Cyclo(phenylalanine‐proline) induces DNA damage in mammalian cells via reactive oxygen species

K Lee, JE Jeong, IH Kim, KS Kim… - Journal of cellular and …, 2015 - Wiley Online Library
Cyclo (phenylalanine‐proline) is produced by various organisms such as animals, plants,
bacteria and fungi. It has diverse biological functions including anti‐fungal activity, anti …

[HTML][HTML] Vibrio tapetis Displays an Original Type IV Secretion System in Strains Pathogenic for Bivalve Molluscs

GM Dias, A Bidault, P Le Chevalier… - Frontiers in …, 2018 - frontiersin.org
The Brown Ring Disease (BRD) caused high mortality rates since 1986 in the Manila clam
Venerupis philippinarum introduced and cultured in Western Europe from the 1970s. The …

[HTML][HTML] H-NS silences gene expression of LeuO, the master regulator of the cyclic (Phe-Pro)-dependent signal pathway, in Vibrio vulnificus

NY Park, KW Lee, KS Kim - Journal of Microbiology and …, 2020 - ncbi.nlm.nih.gov
The histone-like nucleoid structuring protein (H-NS) is an abundant global regulator of
environmentally controlled gene expression. Herein, we demonstrate that H-NS represses …

Cyclo(Phe-Pro) produced by Vibrio species passes through biological membranes by simple diffusion

NY Park, YB Cho, OB Kim, KS Kim - Applied Microbiology and …, 2020 - Springer
Abstract Cyclo (Phe-Pro)(cFP), produced by the Vibrio species, plays the dual roles of being
a signaling molecule and a virulence factor. Acting modes of this compound have recently …