The past decade has witnessed a rapid evolution in identifying more versatile clustered
regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) …

A large and ever-expanding set of CRISPR–Cas systems now enables the rapid and flexible
manipulation of genomes in both targeted and large-scale experiments. Numerous software …

Tumor-specific T cells are frequently exhausted by chronic antigenic stimulation. We here
report on a human antigen-specific ex vivo model to explore new therapeutic options for T …

Ferroptosis has emerged as an attractive strategy in cancer therapy. Understanding the
operational networks regulating ferroptosis may unravel vulnerabilities that could be …

Regulatory T (Treg) cells play a pivotal role in suppressing auto-reactive T cells and
maintaining immune homeostasis. Treg cell development and function are dependent on the …

Pathogens use virulence factors to inhibit the immune system. The guard hypothesis,
postulates that hosts monitor (or 'guard') critical innate immune pathways such that their …

High-throughput genetic screens interfering with gene expression are invaluable tools to
identify gene function and phenotype-to-genotype interactions. Implementing such screens …

Drug resistance and relapse remain key challenges in pancreatic cancer. Here, we have
used RNA sequencing (RNA-seq), chromatin immunoprecipitation (ChIP)-seq, and genome …

Summary Store-operated Ca 2+ entry (SOCE) mediated by stromal interacting molecule
(STIM)-gated ORAI channels at endoplasmic reticulum (ER) and plasma membrane (PM) …

Purpose: Uveal melanoma is the most common eye cancer in adults. Approximately 50% of
patients with uveal melanoma develop metastatic uveal melanoma (mUM) in the liver, even …