Simple Summary Terpenoids are bioactive compounds with a variety of pharmacological
activities, including anticancer activity. This review paper aimed to focus on the anticancer …

Review covering up to 07/2019 (−)-Parthenolide is a germacrane sesquiterpene lactone,
available in ample amounts from the traditional medical plant feverfew (Tanacetum …

Although Michael acceptors display a potent and broad spectrum of bioactivity, they have
largely been ignored in drug discovery because of their presumed indiscriminate reactivity …

The cancer stem cell (CSC) or cancer-initiating cancer (C-IC) model has garnered
considerable attention over the past several years since Dick and colleagues published a …

Highlights•This article highlights phases in parthenolide (PTL) lead anticancer drug
development.•PTL structure–activity relationship studies reveal properties required for …

Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species,
exhibit a broad spectrum of biological effects and several of them are already commercially …

In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress
transduced by the microtubule network elicits reactive oxygen species. X-ROS tunes Ca2+ …

Cancer is one of the main causes of death globally and considered as a major challenge for
the public health system. The high toxicity and the lack of selectivity of conventional …

Primary and acquired resistance of cancer to therapy is often associated with activation of
nuclear factor kappa B (NF-κB). Parthenolide (PN) has been shown to inhibit NF-κB …

The microRNA miR-155 has been implicated in regulating inflammatory responses and
tumorigenesis, but its precise role in linking inflammation and cancer has remained elusive …