Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

Cardiovascular disease is the number one cause of mortality in the Western world. The heart
responds to many cardiopathological conditions with hypertrophic growth by enlarging …

Endothelial-mesenchymal transition (EndMT) is associated with various cardiovascular
diseases and in particular with atherosclerosis and plaque instability. However, the …

Transcriptional coregulators control the activity of many transcription factors and are thought
to have wide-ranging effects on gene expression patterns. We show here that muscle …

Chromatin modifications are sensitive to environmental and nutritional stimuli. Abnormalities
in epigenetic regulation are associated with metabolic disorders such as obesity and …

Cardiovascular diseases (CVDs) remain a leading global cause of morbidity and mortality.
These diseases have a multifaceted nature being influenced by a multitude of biochemical …

Abstract Purpose: Histone deacetylase inhibitors (HDACi) are promising anticancer drugs.
Although some HDACi have entered the clinic, the mechanism (s) underlying their tumor …

Significance: Epigenetic inactivation of pivotal genes involved in cell growth is a hallmark of
human pathologies, in particular cancer. Histone acetylation balance obtained through …

We describe 1, 3, 4-oxadiazole-containing hydroxamates (2) and 2-aminoanilides (3) as
histone deacetylase inhibitors. Among them, 2t, 2x, and 3i were the most potent and …

OBJECTIVE Class IIa histone deacetylases (HDACs) belong to a large family of enzymes
involved in protein deacetylation and play a role in regulating gene expression and cell …