Measuring biological aging in humans: A quest
L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …
The DNA damage response to transcription stress
The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …
ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade
Abstract ARID1A (the AT-rich interaction domain 1A, also known as BAF250a) is one of the
most commonly mutated genes in cancer,. The majority of ARID1A mutations are inactivating …
most commonly mutated genes in cancer,. The majority of ARID1A mutations are inactivating …
Adaptive mutability of colorectal cancers in response to targeted therapies
The emergence of drug resistance limits the efficacy of targeted therapies in human tumors.
The prevalent view is that resistance is a fait accompli: when treatment is initiated, cancers …
The prevalent view is that resistance is a fait accompli: when treatment is initiated, cancers …
WRN helicase is a synthetic lethal target in microsatellite unstable cancers
Synthetic lethality—an interaction between two genetic events through which the co-
occurrence of these two genetic events leads to cell death, but each event alone does not …
occurrence of these two genetic events leads to cell death, but each event alone does not …
DNA mismatch repair and the DNA damage response
Z Li, AH Pearlman, P Hsieh - DNA repair, 2016 - Elsevier
This review discusses the role of DNA mismatch repair (MMR) in the DNA damage response
(DDR) that triggers cell cycle arrest and, in some cases, apoptosis. Although the focus is on …
(DDR) that triggers cell cycle arrest and, in some cases, apoptosis. Although the focus is on …
Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming
S Koster, RK Gurumurthy, N Kumar, PG Prakash… - Nature …, 2022 - nature.com
Coinfections with pathogenic microbes continually confront cervical mucosa, yet their
implications in pathogenesis remain unclear. Lack of in-vitro models recapitulating cervical …
implications in pathogenesis remain unclear. Lack of in-vitro models recapitulating cervical …
The balance between NRF2/GSH antioxidant mediated pathway and DNA repair modulates cisplatin resistance in lung cancer cells
Lung cancer patients face a dismal prognosis mainly due to the low efficacy of current
available treatments. Cisplatin is the first-line chemotherapy treatment for those patients …
available treatments. Cisplatin is the first-line chemotherapy treatment for those patients …
Temozolomide in the era of precision medicine
A Thomas, M Tanaka, J Trepel, WC Reinhold… - Cancer research, 2017 - AACR
Abstract In the January 1, 2017, issue of Cancer Research, Nagel and colleagues
demonstrate the value of assays that determine the DNA repair capacity of cancers in …
demonstrate the value of assays that determine the DNA repair capacity of cancers in …
The key characteristics of carcinogens: relationship to the hallmarks of cancer, relevant biomarkers, and assays to measure them
The key characteristics (KC) of human carcinogens provide a uniform approach to
evaluating mechanistic evidence in cancer hazard identification. Refinements to the …
evaluating mechanistic evidence in cancer hazard identification. Refinements to the …