Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis
BD Needham, MS Trent - Nature Reviews Microbiology, 2013 - nature.com
Gram-negative bacteria decorate their outermost surface structure, lipopolysaccharide, with
elaborate chemical moieties, which effectively disguises them from immune surveillance and …
elaborate chemical moieties, which effectively disguises them from immune surveillance and …
[HTML][HTML] Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system
The dominant conceptual framework for understanding innate immunity has been that host
cells respond to evolutionarily conserved molecular features of pathogens called pathogen …
cells respond to evolutionarily conserved molecular features of pathogens called pathogen …
Of PAMPs and effectors: the blurred PTI-ETI dichotomy
Typically, pathogen-associated molecular patterns (PAMPs) are considered to be conserved
throughout classes of microbes and to contribute to general microbial fitness, whereas …
throughout classes of microbes and to contribute to general microbial fitness, whereas …
The NLRP12 inflammasome recognizes Yersinia pestis
Yersinia pestis, the causative agent of plague, is able to suppress production of
inflammatory cytokines IL-18 and IL-1β, which are generated through caspase-1-activating …
inflammatory cytokines IL-18 and IL-1β, which are generated through caspase-1-activating …
Recognition of lipid A variants by the TLR4-MD-2 receptor complex
N Maeshima, RC Fernandez - Frontiers in cellular and infection …, 2013 - frontiersin.org
Lipopolysaccharide (LPS) is a component of the outer membrane of almost all Gram-
negative bacteria and consists of lipid A, core sugars, and O-antigen. LPS is recognized by …
negative bacteria and consists of lipid A, core sugars, and O-antigen. LPS is recognized by …
Structural modifications of bacterial lipopolysaccharide that facilitate gram-negative bacteria evasion of host innate immunity
M Matsuura - Frontiers in immunology, 2013 - frontiersin.org
Bacterial lipopolysaccharide (LPS), a cell wall component characteristic of Gram-negative
bacteria, is a representative pathogen-associated molecular pattern that allows mammalian …
bacteria, is a representative pathogen-associated molecular pattern that allows mammalian …
LPS remodeling is an evolved survival strategy for bacteria
Y Li, DA Powell, SA Shaffer… - Proceedings of the …, 2012 - National Acad Sciences
Maintenance of membrane function is essential and regulated at the genomic,
transcriptional, and translational levels. Bacterial pathogens have a variety of mechanisms …
transcriptional, and translational levels. Bacterial pathogens have a variety of mechanisms …
Bilayer properties of lipid A from various Gram-negative bacteria
Lipid A is the lipid anchor of a lipopolysaccharide in the outer leaflet of the outer membrane
of Gram-negative bacteria. In general, lipid A consists of two phosphorylated N-acetyl …
of Gram-negative bacteria. In general, lipid A consists of two phosphorylated N-acetyl …
Porphyromonas gingivalis outer membrane vesicles as the major driver of and explanation for neuropathogenesis, the cholinergic hypothesis, iron dyshomeostasis …
PL Nara, D Sindelar, MS Penn… - Journal of …, 2021 - content.iospress.com
Porphyromonas gingivalis (Pg) is a primary oral pathogen in the widespread biofilm-induced
“chronic” multi-systems inflammatory disease (s) including Alzheimer's disease (AD). It is …
“chronic” multi-systems inflammatory disease (s) including Alzheimer's disease (AD). It is …
Rationally designed TLR4 ligands for vaccine adjuvant discovery
KA Gregg, E Harberts, FM Gardner, MR Pelletier… - MBio, 2017 - Am Soc Microbiol
Adjuvant properties of bacterial cell wall components like MPLA (monophosphoryl lipid A)
are well described and have gained FDA approval for use in vaccines such as Cervarix …
are well described and have gained FDA approval for use in vaccines such as Cervarix …