Parkinson's disease (PD) is a chronic and progressive neurodegeneration of dopamine
neurons in the substantia nigra. The reason for the death of these neurons is unclear; …

A pathological feature of Parkinson's disease (PD) is the progressive loss of dopaminergic
neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD …

Quantifying tissue iron concentration in vivo is instrumental for understanding the role of iron
in physiology and in neurological diseases associated with abnormal iron distribution …

Purpose To investigate the relationship between transverse relaxation rates R2 and R2*, the
most frequently used surrogate markers for iron in brain tissue, and chemically determined …

Rapid increase in aging populations is an urgent problem because older adults are more
likely to suffer from disabilities and age-related diseases (ARDs), burdening healthcare …

A growing set of observations points to mitochondrial dysfunction, iron accumulation,
oxidative damage and chronic inflammation as common pathognomonic signs of a number …

The link between brain iron homeostasis and neurodegenerative disease has been the
subject of extensive research. There is increasing evidence of iron accumulation during …

Purpose: To determine if tissue magnetic susceptibility is a more direct marker of tissue iron
content than other MR markers of iron. This study presents the first quantitative, in vivo …

Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and
myelin production. Though iron deposition has been observed in the brain with normal …

Parkinson disease (PD) is associated with nigral degeneration and striatal dopamine
deficiency. Demonstrating midbrain structural abnormalities with transcranial sonography or …