Preeclampsia is defined as new-onset hypertension after the 20th wk of gestation along with
evidence of maternal organ failure. Rates of preeclampsia have steadily increased over the …

I. Introduction T HE calcitonin (CT) and calcitonin gene-related peptide (CGRP) are derived
from the CT/CGRP gene, which is localized in chromosome 11. Alternative splicing of the …

First published in 1990: The Endothelium: Modulator of Cardiovascular Function takes a
comprehensive look at the role of the endothelium in cardiovascular control in health and …

Vascular smooth muscle tone is controlled by a balance between the cellular signaling
pathways that mediate the generation of force (vasoconstriction) and release of force …

NO, produced from l-arginine in a reaction catalyzed by NO synthase, is an endogenous free
radical with multiple functions in mammalian cells. Here, we demonstrate that endogenously …

The role of cGMP-dependent protein kinase in the regulation of intracellular Ca2 levels in
vascular smooth muscle cells was examined by studying the effects of cGMP on the …

This review is the result of a widening interest in the role of cGMP in vascular smooth muscle
function. Smooth muscle physiologists, pharmacologists, and biochemists now appreciate …

Previous studies have demonstrated that cGMP and cAMP reduce the endothelial
permeability for fluids and macromolecules when the endothelial permeability is increased …

Phospholamban of isolated sarcoplasmic reticulum of cardiac and smooth muscle is
phosphorylated by cyclic GMP-dependent protein kinase (G-kinase). Concomitantly, the …

Primary rat aortic cells, when treated with arginine vasopressin or depolarizing
concentrations of K+, responded to atriopeptin II and 8-bromo-cGMP (8-Br-cGMP) with …