This analytical review summarizes literature data and our own research on HSP70-
dependent mechanisms of neuroprotection and discusses potential pharmacological agents …

In the last years there has been a considerable advance in the knowledge on the regulation
of astrocytes by sex steroids under physiological and pathological conditions. By the …

The steroidal drug Tibolone is used for the treatment of climacteric symptoms and
osteoporosis in post-menopausal women. Although Tibolone has been shown to exert …

Inflammation is a complex biological response to injuries, metabolic disorders or infections.
In the brain, astrocytes play an important role in the inflammatory processes during …

Obesity has been associated with increased chronic neuroinflammation and augmented risk
of neurodegeneration. This is worsened during the normal aging process when the levels of …

Several lines of evidence have suggested that mitochondrial dysfunction plays a key role in
neurodegeneration. The mitochondrial function is a potential target for steroid hormones …

The authors propose a novel approach to a comprehensive evaluation of neuroprotective
effects using both in vitro and in vivo methods. This approach allows for the initial screening …

Neurotransmitters are chemical messengers synthesized by neurons, which enable
interconnection of nerve fibers within their vicinity. Neurotransmitters traditionally consist of …

We studied the neurochemical aspects of the neuroprotective action of a selective modulator
of the estrogen receptors, tamoxifen citrate, in a model of acute cerebral ischemia (ACI). It …

Aim of study–to evaluate the SERM cardioprotective effects in the conditions of acute
myocardial infarction modelling with the use of the ST2 marker. Materials and methods. The …