The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-
dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that …

Myeloid cells, including parenchymal microglia, perivascular and meningeal macrophages,
and dendritic cells (DCs), are present in the central nervous system (CNS) and establish an …

Transcription factors directly regulate gene expression by recognizing and binding to
specific DNA sequences, involving the dynamic alterations of chromatin structure and the …

Efficient neurotransmission is essential for organism survival and is enhanced by
myelination. However, the genes that regulate myelin and myelinating glial cell development …

The sirtuins (SIRTs), a class of NAD+-dependent deacylases, contain seven SIRT family
members in mammals, from SIRT1 to SIRT7. Extensive studies have revealed that SIRT …

Multiple sclerosis (MS) is a complex and multifactorial neurodegenerative disease with
unknown etiology, MS is featured by multifocal demyelinated lesions distributed throughout …

Recent advances in understanding the pathogenesis of multiple sclerosis (MS) have
brought into the spotlight the major role played by reactive astrocytes in this condition …

Cannabinoid signaling, mainly via CB1 and CB2 receptors, plays an essential role in
oligodendrocyte health and functions. However, the specific molecular signals associated …

The terminal complement complex (TCC) has been described as a potential driver in the
pathogenesis of posttraumatic osteoarthritis (PTOA). However, sublytic TCC deposition …

Objective and design To elucidate Sirt1's role in gouty arthritis inflammation and its potential
mechanisms. Material Constructed murine models of gouty arthritis and conducted THP-1 …