Rational drug design implies usage of molecular modeling techniques such as
pharmacophore modeling, molecular dynamics, virtual screening, and molecular docking to …

The treatment of advanced non‐small cell lung cancer (NSCLC) has made substantial
progress due to the rapid development of small molecule targeted therapy, with dramatically …

Tumorigenesis in humans is a multistep progression that imitates genetic changes leading
to cell transformation and malignancy. Oncogenic kinases play a central role in cancer …

Cellular senescence is a barrier to tumorigenesis in normal cells, and tumor cells undergo
senescence responses to genotoxic stimuli, which is a potential target phenotype for cancer …

Histone deacetylases (HDACs) are important epigenetic regulators that modulate the activity
of histone and non-histone proteins leading to various cancers. Histone deacetylase 1 …

Targeting ErbB family of receptors is an important therapeutic option, because of its
essential role in the broad spectrum of human cancers, including non-small cell lung cancer …

Background: Camptothecin is a quinoline alkaloid, isolated from the Chinese tree
Camptotheca acuminate which exhibits its cytotoxic activity by the inhibition of nuclear …

Cancer cells are described with features of uncontrolled growth, invasion and metastasis.
The epidermal growth factor receptor subfamily of tyrosine kinases (EGFR-TK) plays a …

Objective: Identifying new inhibitors of Epidermal Growth Factor Receptor (EGFR) by virtual
screening using a pharmacophore model followed by docking. Methods: A pharmacophore …

Pim-3 (proviral integration site moloney murine leukemia virus-3) is an oncogene which
encodes proteins belonging to serine/threonine kinase family and PIM subfamily. It is …