Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …

The tumor microenvironment has been identified as one of the driving factors of tumor
progression and invasion. Inside this microenvironment, cancer‐associated fibroblasts …

Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …

In vitro 3D models are advanced biological tools that have been established to overcome
the shortcomings of oversimplified 2D cultures and mouse models. Various in vitro 3D …

Summary The cytokine interleukin-6 (IL6) and its downstream effector STAT3 constitute a
key oncogenic pathway, which has been thought to be functionally connected to estrogen …

Seaweeds have been generally utilized as food and alternative medicine in different
countries. They are specifically used as a raw material for wine, cheese, soup, tea, noodles …

The mechanisms behind cancer initiation and progression are not clear. Therefore,
development of clinically relevant models to study cancer biology and drug response in …

The tumour microenvironment (TME) shapes disease progression and influences
therapeutic response. Most aggressive solid tumours have high levels of myeloid cell …

Three-dimensional multicellular tumor models are receiving an ever-growing focus as
preclinical drug-screening platforms due to their potential to recapitulate major physiological …