Uveal melanoma is the most common primary malignancy of the eye, and a number of
discoveries in the last decade have led to a more thorough molecular characterization of this …

Abstract Glycine 34-to-tryptophan (G34W) substitutions in H3. 3 arise in approximately 90%
of giant cell tumor of bone (GCT). Here, we show H3. 3 G34W is necessary for tumor …

Proton minibeam radiation therapy (pMBRT) is a novel strategy which has already shown a
remarkable reduction in neurotoxicity as to compared with standard proton therapy. Here we …

Introduction Metastatic rhabdomyosarcoma (RMS) is a challenging tumor entity that evades
conventional treatments and endogenous antitumor immune responses, highlighting the …

Purpose: Mutational activation of GNAQ or GNA11 (GNAQ/11), detected in> 90% of uveal
melanomas, leads to constitutive activation of oncogenic pathways, including MAPK and …

Transgenic breast cancer mouse models are critical tools for preclinical studies of human
breast cancer. Genetic editing of the murine mammary gland allows for modeling of …

Background & Aims Since human induced pluripotent stem cells (iPSCs) develop into
hepatic organoids through stages that resemble human embryonic liver development, they …

In metastatic breast cancer, HER2-activating mutations frequently co-occur with mutations in
PIK3CA, TP53, or CDH1. Of these co-occurring mutations, HER2 and PIK3CA are the most …

Metastatic castration resistant prostate cancer (mCRPC) relapses due to acquired resistance
to docetaxel-based chemotherapy and remains a major threat to patient survival. In this …

Background Uveal melanoma (UM) is a highly aggressive disease with very few treatment
options. We previously demonstrated that mUM is characterized by high oxidative …