[HTML][HTML] Myocardin in biology and disease

JM Miano - Journal of biomedical research, 2015 - ncbi.nlm.nih.gov
Myocardin (MYOCD) is a potent transcriptional coactivator that functions primarily in cardiac
muscle and smooth muscle through direct contacts with serum response factor (SRF) over …

Emerging roles for RNA-binding proteins as effectors and regulators of cardiovascular disease

RG de Bruin, TJ Rabelink… - European heart …, 2017 - academic.oup.com
The cardiovascular system comprises multiple cell types that possess the capacity to
modulate their phenotype in response to acute or chronic injury. Transcriptional and post …

CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p

Y Xi, Y Shen, D Wu, J Zhang, C Lin, L Wang, C Yu… - Molecular cancer, 2022 - Springer
Abstract Rationale Circular RNAs (circRNAs) have been demonstrated to contribute to
esophageal cancer progression. CircBCAR3 (hsa_circ_0007624) is predicted to be …

The RNA-binding protein QKI suppresses cancer-associated aberrant splicing

FY Zong, X Fu, WJ Wei, YG Luo, M Heiner, LJ Cao… - PLoS …, 2014 - journals.plos.org
Lung cancer is the leading cause of cancer-related death worldwide. Aberrant splicing has
been implicated in lung tumorigenesis. However, the functional links between splicing …

Shear stress regulation of endothelial glycocalyx structure is determined by glucobiosynthesis

G Wang, S Kostidis, GL Tiemeier… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Endothelial cells exposed to laminar shear stress express a thick glycocalyx on
their surface that plays an important role in reducing vascular permeability and endothelial …

QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function

X Chen, Y Liu, C Xu, L Ba, Z Liu, X Li, J Huang… - Nature …, 2021 - nature.com
The RNA-binding protein QKI belongs to the hnRNP K-homology domain protein family, a
well-known regulator of pre-mRNA alternative splicing and is associated with several …

Alternative splicing and related RNA binding proteins in human health and disease

Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal Transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

MiR-143-3p functions as a tumor suppressor by regulating cell proliferation, invasion and epithelial–mesenchymal transition by targeting QKI-5 in esophageal …

Z He, J Yi, X Liu, J Chen, S Han, L Jin, L Chen, H Song - Molecular cancer, 2016 - Springer
Abstract Background Dysregulation of microRNAs (miRNAs) have been demonstrated to
contribute to carcinogenesis. MiR-143-3p has been identified to function as a tumor …

Myocardin regulates vascular smooth muscle cell inflammatory activation and disease

M Ackers-Johnson, A Talasila, AP Sage… - … , and vascular biology, 2015 - Am Heart Assoc
Objective—Atherosclerosis, the cause of 50% of deaths in westernized societies, is widely
regarded as a chronic vascular inflammatory disease. Vascular smooth muscle cell (VSMC) …

The Quaking RNA‐binding proteins as regulators of cell differentiation

DP Neumann, GJ Goodall… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
The RNA‐binding protein Quaking (QKI) has emerged as a potent regulator of cellular
differentiation in developmental and pathological processes. The QKI gene is itself …