Synthetic microbiology in sustainability applications

EM Jones, JP Marken, PA Silver - Nature Reviews Microbiology, 2024 - nature.com
Microorganisms are a promising means to address many societal sustainability challenges
owing to their ability to thrive in diverse environments and interface with the microscale …

Positive feedback amplification in swarming immune cell populations

KM Glaser, M Mihlan, T Lämmermann - Current Opinion in Cell Biology, 2021 - Elsevier
Several immune cell types (neutrophils, eosinophils, T cells, and innate-like lymphocytes)
display coordinated migration patterns when a population, formed of individually responding …

Ultrafast distant wound response is essential for whole-body regeneration

Y Fan, C Chai, P Li, X Zou, JE Ferrell, B Wang - Cell, 2023 - cell.com
Injury induces systemic responses, but their functions remain elusive. Mechanisms that can
rapidly synchronize wound responses through long distances are also mostly unknown …

Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming

E Strickland, D Pan, C Godfrey, JS Kim, A Hopke… - Developmental Cell, 2024 - cell.com
Neutrophils collectively migrate to sites of injury and infection. How these swarms are
coordinated to ensure the proper level of recruitment is unknown. Using an ex vivo model of …

Modeling the Reactive Oxygen Species (ROS) wave in Chlamydomonas reinhardtii colonies

Y Zhou, Y Fichman, S Zhang, R Mittler… - Free Radical Biology and …, 2024 - Elsevier
Reactive oxygen species (ROS) play a crucial role as signaling molecules in both plant and
animal cells, enabling rapid responses to various stimuli. Among the many cellular …

Transcellular biosynthesis of leukotriene B4 orchestrates neutrophil swarming to fungi

A Hopke, T Lin, AK Scherer, AE Shay, KD Timmer… - Iscience, 2022 - cell.com
Neutrophil swarming is an emergent host defense mechanism triggered by targets larger
than a single neutrophil's capacity to phagocytose. Swarming synergizes neutrophil …

Design principles of tissue organisation: How single cells coordinate across scales

M Zinner, I Lukonin, P Liberali - Current opinion in cell biology, 2020 - Elsevier
Cells act as building blocks of multicellular organisms, forming higher-order structures at
different biological scales. Niches, tissues and, ultimately, entire organisms consist of single …

Long-range morphogen gradient formation by cell-to-cell signal propagation

JEM Dickmann, JC Rink, F Jülicher - Physical biology, 2022 - iopscience.iop.org
Morphogen gradients are a central concept in developmental biology. Their formation often
involves the secretion of morphogens from a local source, that spread by diffusion in the cell …

Large-scale-integration and collective oscillations of 2D artificial cells

J Ricouvier, P Mostov, O Shabtai, O Vonshak… - Nature …, 2024 - nature.com
The on-chip large-scale-integration of genetically programmed artificial cells capable of
exhibiting collective expression patterns is important for fundamental research and …

Regeneration: signaling superhighways

F Sun, A De Simone, KD Poss - Current Biology, 2023 - cell.com
Regeneration requires the collective effort of multiple organ systems. A recent study of
planarian whole-body regeneration finds that Erk kinase activity propagates rapidly across …