Several neurological diseases are characterized by the altered activity of one or a few
ubiquitously expressed cell proteins, but it is not known how these normal proteins turn into …

A large number of mammalian Mg2+ transporters have been hypothesized on the basis of
physiological data, but few have been investigated at the molecular level. The recent …

OBJECTIVE: The Hox gene family of transcription factors is thought to be involved in the
regulation of primitive hematopoietic cells, including stem cells and early committed …

Background Huntington's disease (HD) pathogenesis is due to an expanded polyglutamine
tract in huntingtin, but the specificity of neuronal loss compared with other polyglutamine …

Abstract Huntington's disease (HD), with its selective neuronal cell loss, is caused by an
elongated glutamine tract in the huntingtin protein. To discover the pathways that are …

Huntington's disease (HD) is one of many neurodegenerative diseases with reported
alterations in brain iron homeostasis that may contribute to neuropathogenesis. Iron …

The insulin‐like growth factor I (IGF‐1)/Akt pathway plays a crucial role in Huntington's
disease by phosphorylating the causative protein, polyQ‐huntingtin, and abolishing its toxic …

Huntington's disease (HD) is one of nine neurodegenerative disorders caused by expansion
of CAG repeats encoding polyglutamine in their respective, otherwise apparently unrelated …

Transglutaminases (TGases) are enzymes that are widely used in many biological systems
for generic tissue stabilization purposes. Mutations resulting in lost activity underlie several …

Huntington disease is an adult-onset neurodegenerative disorder that is caused by the
expansion of a polyglutamine tract within the Huntingtin (htt) protein. Wild-type htt has been …