This review presents a comprehensive discussion of the clinical condition of delayed
puberty, a common presentation to the pediatric endocrinologist, which may present both …

Puberty identifies the transition from childhood to adulthood. Precocious puberty is the onset
of signs of pubertal development before age eight in girls and before age nine in boys, it has …

Background/Aims: Recently, loss-of-function mutations in the MKRN3 gene have been
implicated in the etiology of familial central precocious puberty (CPP) in both sexes. We …

Background Recent studies demonstrated that changes in DNA methylation (DNAm) and
inactivation of two imprinted genes (MKRN3 and DLK1) alter the onset of female puberty …

OBJECTIVES: The aim of this study is to present a survey of vulnerabilities and to suggest
approaches for the treatment of rare diseases according to the perceptions of a group of …

Background: The objective of the study was to determine the stress levels of girls with central
precocious puberty (CPP) before and during treatment with a long-acting gonadotropin …

Background: Loss-of-function mutations in the imprinted gene MKRN3 represent the most
common known genetic defects associated with central precocious puberty (CPP). Methods …

OBJECTIVES: Unfavorable predicted adult height and psychosocial inadequacy represent
parameters used to guide therapeutic intervention in girls with central precocious puberty …

Classically, the normal chronological age for pubertal onset is between 8 and 13 years in
girls and 9 and 14 years in boys based on data from epidemiological studies from the 60's …

Objective To report our experience of treating central precocious puberty (CPP) with a GnRH
analogue with respect to the final heights (FH) attained in patients who completed treatment …