Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …

Lysosomes are cytoplasmic organelles that contain a variety of different hydrolases. A
genetic deficiency in the enzymatic activity of one of these hydrolases will lead to the …

Repurposing drugs as treatments for COVID-19, the disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has drawn much attention. Beginning …

We report the development of a 3D OrbiSIMS instrument for label-free biomedical imaging. It
combines the high spatial resolution of secondary ion mass spectrometry (SIMS; under 200 …

Lysosomes critically rely on bis (monoacylglycero) phosphate (BMP) to stimulate lipid
catabolism, cholesterol homeostasis, and lysosomal function. Alterations in BMP levels in …

Inhibition of the kinase activity of leucine-rich repeat kinase 2 (LRRK2) is under investigation
as a possible treatment for Parkinson's disease. However, there is no clinical validation as …

Drug-induced phospholipidosis is a lysosomal storage disorder characterized by excessive
accumulation of phospholipids. Its cellular mechanism is still not well understood, but it is …

Non-alcoholic fatty liver disease encompasses a spectrum of liver diseases, including
simple steatosis, steatohepatitis, liver fibrosis and cirrhosis and hepatocellular carcinoma …

Severe acute respiratory coronavirus 2 (SARS-CoV-2) is a newly identified virus that has
resulted in over 2.5 million deaths globally and over 116 million cases globally in March …

Lysosomes catabolize and recycle lipids and other biological molecules to maintain cellular
homeostasis in diverse nutrient environments. Lysosomal lipid catabolism relies on the …